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Chemical modification of enzymes: reaction with an unstable inhibitor.

作者信息

Topham C M

出版信息

Biochem J. 1985 May 1;227(3):1025-7. doi: 10.1042/bj2271025.

DOI:10.1042/bj2271025
PMID:4004791
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1144937/
Abstract
摘要

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Alternative methods for the determination of rate constants describing enzyme inactivation by an unstable inhibitor.测定不稳定抑制剂使酶失活的速率常数的替代方法。
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引用本文的文献

1
Experimental approach to the kinetic study of unstable site-directed irreversible inhibitors: kinetic origin of the apparent positive co-operativity arising from inactivation of trypsin by p-amidinophenylmethanesulphonyl fluoride.不稳定的定点不可逆抑制剂动力学研究的实验方法：对氨基苯甲脒基甲磺酰氟使胰蛋白酶失活产生的表观正协同性的动力学起源
Biochem J. 1994 Apr 1;299 ( Pt 1)(Pt 1):29-35. doi: 10.1042/bj2990029.
2
Computer simulations of the kinetics of irreversible enzyme inhibition by an unstable inhibitor.不稳定抑制剂对酶不可逆抑制动力学的计算机模拟
Biochem J. 1986 Dec 15;240(3):817-20. doi: 10.1042/bj2400817.
3
Alternative methods for the determination of rate constants describing enzyme inactivation by an unstable inhibitor.测定不稳定抑制剂使酶失活的速率常数的替代方法。
Biochem J. 1987 Sep 15;246(3):804-6. doi: 10.1042/bj2460804.
4
Making sense of the kinetics of reactions of unstable modifiers with enzymes.理解不稳定修饰剂与酶反应的动力学。
Biochem J. 1992 Oct 1;287 ( Pt 1)(Pt 1):334-5. doi: 10.1042/bj2870334.

本文引用的文献

1
Some properties of specific cholinesterase with particular reference to the mechanism of inhibition by diethyl p-nitrophenyl thiophosphate (E 605) and analogues.特异性胆碱酯酶的某些特性，特别涉及对硫代磷酸O,O-二乙基对硝基苯酯（E605）及其类似物的抑制机制。
Biochem J. 1950 Apr;46(4):451-60. doi: 10.1042/bj0460451.
2
A method for characterizing the type and numbers of groups involved in enzyme action.一种表征参与酶作用的基团类型和数量的方法。
J Biol Chem. 1961 Jul;236:1973-9.
3
Kinetics of irreversible enzyme inhibition by an unstable inhibitor.不稳定抑制剂对酶的不可逆抑制动力学
Biochem J. 1981 Nov 1;199(2):462-3. doi: 10.1042/bj1990462.
4
Evidence for an essential histidine residue in S-adenosylhomocysteinase from rat liver.大鼠肝脏S-腺苷同型半胱氨酸酶中必需组氨酸残基的证据。
Biochemistry. 1983 Jan 4;22(1):137-43. doi: 10.1021/bi00270a020.
5
Kinetics of protein modification reactions.蛋白质修饰反应的动力学
Biochem J. 1984 Jan 15;217(2):341-51. doi: 10.1042/bj2170341.
6
The kinetics of the reaction of N,N-dimethyl-2-phenylaziridinium ion with bovine erythrocyte acetylcholinesterase.N,N-二甲基-2-苯基氮杂环丙烷离子与牛红细胞乙酰胆碱酯酶反应的动力学
Can J Biochem. 1970 Mar;48(3):244-50. doi: 10.1139/o70-044.
7
The inhibition of cholinesterase by diethyl phosphorochloridate.二乙基氯磷酸酯对胆碱酯酶的抑制作用。
Biochim Biophys Acta. 1972 Oct 12;284(2):427-34. doi: 10.1016/0005-2744(72)90139-8.
8
Kinetics of irreversible enzyme inhibition by an unstable inhibitor.不稳定抑制剂对酶的不可逆抑制动力学
Biochem J. 1974 Aug;141(2):601-3. doi: 10.1042/bj1410601.
9
Kinetics of irreversible enzyme inhibition: co-operative effects.不可逆酶抑制动力学：协同效应
J Theor Biol. 1977 Jul 7;67(1):49-59. doi: 10.1016/0022-5193(77)90184-9.
10
Kinetics of irreversible enzyme inhibition by an unstable inhibitor: co-operative effects.不稳定抑制剂对不可逆酶抑制作用的动力学：协同效应
J Theor Biol. 1978 Nov 21;75(2):239-43. doi: 10.1016/0022-5193(78)90233-3.