Mazurek Jacek M, Syamlal Girija, Weissman David N
Respiratory Health Division, National Institute for Occupational Safety and Health, CDC.
MMWR Morb Mortal Wkly Rep. 2025 Mar 6;74(7):109-115. doi: 10.15585/mmwr.mm7407a1.
Idiopathic pulmonary fibrosis (IPF), a progressive lung disease characterized by scarring and worsening lung function, has a poor prognosis. A recent systematic review estimated that 21% of IPF deaths might be attributable to occupational exposures. To describe IPF mortality among U.S. residents aged ≥15 years who were ever employed, by industry and occupation, CDC conducted an exploratory analysis of 2020-2022 multiple cause-of-death data. During 2020-2022, a total of 67,843 (39,712 [59%] male and 28,131 [41%] female) decedents had IPF, suggesting that during this 3-year period, 8,340 IPF deaths in males and 5,908 deaths in females might have been associated with occupational exposures. By industry group, the highest proportionate mortality ratios among males were among those employed in utilities (1.15) and among females, were among those employed in public administration (1.12). By occupation group, the highest IPF mortality rates among males were among community and social services workers (1.23) and among females among farming, fishing, and forestry workers (1.24). Estimates of elevated IPF mortality among workers in specific industries and occupations warrant confirmation, control of known exposure-related risk factors, and continued surveillance to better understand the full range of occupational exposures that might increase risk for developing IPF.
特发性肺纤维化(IPF)是一种以肺组织瘢痕形成和肺功能恶化为特征的进行性肺部疾病,预后较差。最近一项系统评价估计,21%的IPF死亡可能归因于职业暴露。为按行业和职业描述≥15岁曾就业的美国居民中的IPF死亡率,美国疾病控制与预防中心(CDC)对2020 - 2022年的多死因数据进行了探索性分析。在2020 - 2022年期间,共有67843名(39712名[59%]男性和28131名[41%]女性)死者患有IPF,这表明在这3年期间,男性中有8340例IPF死亡和女性中有5908例死亡可能与职业暴露有关。按行业组划分,男性中比例死亡率最高的是从事公用事业的人员(1.15),女性中比例死亡率最高的是从事公共管理的人员(1.12)。按职业组划分,男性中IPF死亡率最高的是社区和社会服务工作者(1.23),女性中IPF死亡率最高的是从事农业、渔业和林业的人员(1.24)。特定行业和职业的工人中IPF死亡率升高的估计值有待确认,需要控制已知的与暴露相关的风险因素,并持续进行监测,以更好地了解可能增加患IPF风险的所有职业暴露情况。