双香豆素诱导大鼠肝线粒体释放钙。

Divicine induces calcium release from rat liver mitochondria.

作者信息

Graf M, Frei B, Winterhalter K H, Richter C

出版信息

Biochem Biophys Res Commun. 1985 May 31;129(1):18-25. doi: 10.1016/0006-291x(85)91396-8.

Abstract

Divicine, a pyrimidine aglycone strongly implicated in the pathogenesis of favism, induces calcium release from intact rat liver mitochondria. Divicine-dependent calcium release is accompanied by oxidation and hydrolysis of intramitochondrial pyridine nucleotides. Inhibition of both mitochondrial glutathione peroxidase and glutathione reductase slows down divicine-induced calcium release. Cyanide-insensitive respiration indicates redox cycling of divicine in mitochondria. The results suggest that attention should be paid to the action of divicine in cells other than red blood cells.

摘要

蚕豆嘧啶，一种与蚕豆病发病机制密切相关的嘧啶苷元，可诱导完整大鼠肝线粒体释放钙。蚕豆嘧啶依赖性钙释放伴随着线粒体内吡啶核苷酸的氧化和水解。线粒体谷胱甘肽过氧化物酶和谷胱甘肽还原酶的抑制均减缓了蚕豆嘧啶诱导的钙释放。氰化物不敏感呼吸表明蚕豆嘧啶在线粒体内进行氧化还原循环。结果提示，应关注蚕豆嘧啶在红细胞以外的其他细胞中的作用。