Kawashima H, Kurozumi S, Hashimoto Y
Biochem Pharmacol. 1985 Jun 1;34(11):1901-6. doi: 10.1016/0006-2952(85)90306-5.
The interactions of calcium-regulating hormones, active forms of vitamin D and parathyroid hormone, and aspirin were studied in rats. Aspirin, a prostaglandin biosynthesis inhibitor, abolished the hypercalcemia induced by 1 alpha-hydroxyvitamin D3 at 20, 50 and 100 mg/kg p.o. in parathyroidectomized or thyroparathyroidectomized rats with or without vitamin D deficiency, and in thyroparathyroidectomized plus nephrectomized rats. Aspirin did not affect the stimulation of intestinal calcium absorption by 1 alpha-hydroxyvitamin D3. By contrast, indomethacin, another prostaglandin biosynthesis inhibitor, did not affect hypercalcemia or stimulation of intestinal calcium absorption by 1 alpha-hydroxyvitamin D3. Aspirin also abolished the hypercalcemic action of parathyroid hormone in rats with or without intact thyroparathyroid glands. Moreover, aspirin alone caused hypocalcemia in rats with intact thyroparathyroid glands. Indomethacin had no effect in either of these systems. These data suggest that aspirin may inhibit bone resorption by the active form of vitamin D or parathyroid hormone via a mechanism independent of prostaglandin biosynthesis inhibition.
在大鼠中研究了钙调节激素、活性形式的维生素D和甲状旁腺激素与阿司匹林之间的相互作用。阿司匹林是一种前列腺素生物合成抑制剂，它可消除甲状旁腺切除或甲状腺甲状旁腺切除的大鼠（无论有无维生素D缺乏）以及甲状腺甲状旁腺切除加肾切除的大鼠经口服20、50和100mg/kg的1α-羟基维生素D3所诱导的高钙血症。阿司匹林不影响1α-羟基维生素D3对肠道钙吸收的刺激作用。相比之下，另一种前列腺素生物合成抑制剂吲哚美辛不影响1α-羟基维生素D3所致的高钙血症或对肠道钙吸收的刺激作用。阿司匹林还消除了无论甲状腺甲状旁腺是否完整的大鼠中甲状旁腺激素的高钙血症作用。此外，单独使用阿司匹林会使甲状腺甲状旁腺完整的大鼠出现低钙血症。吲哚美辛在这两个系统中均无作用。这些数据表明，阿司匹林可能通过一种独立于前列腺素生物合成抑制的机制，抑制活性形式的维生素D或甲状旁腺激素对骨吸收的作用。
