Coombes R C, Neville A M, Bondy P K, Powles T J
Prostaglandins. 1976 Dec;12(6):1027-35. doi: 10.1016/0090-6980(76)90136-2.
Prostaglandin synthetase inhibitors have, in the past, been shown to inhibit osteolysis caused by breast carcinoma tissue in vitro. We therefore assessed the effect of Indomethacin and aspirin on some parameters of calcium metabolism in patients with breast cancer. Neither drug reduced the serum calcium in pateints with hypercalcemia, nor reduced skeletal destruction as measured by the urinary hydroxy proline: creatinine ratio and urinary calcium in normocalcemic or hypercalcemic patients with osteolytic metastases. A possible reason for the discrepancy between results obtained in vitro and in vivo is that there are two phases of bone destruction in breast cancer; the early phase dependent and the late phase independent of prostaglandin synthesis.
过去已证明前列腺素合成酶抑制剂在体外可抑制乳腺癌组织引起的骨溶解。因此，我们评估了吲哚美辛和阿司匹林对乳腺癌患者钙代谢某些参数的影响。这两种药物均未降低高钙血症患者的血清钙，也未降低骨溶解性转移的血钙正常或高钙血症患者尿羟脯氨酸：肌酐比值和尿钙所测得的骨骼破坏。体外和体内所得结果存在差异的一个可能原因是，乳腺癌的骨破坏有两个阶段；早期阶段依赖前列腺素合成，晚期阶段则不依赖。
