Wünsch E, Moroder L, Nyfeler R, Kalbacher H, Gemeiner M
Biol Chem Hoppe Seyler. 1985 Jan;366(1):53-61. doi: 10.1515/bchm3.1985.366.1.53.
A new synthesis of N-maleoyl-omega-amino acids, their use for the introduction of the maleimido group into peptide factors as well as the stability of this group under standard conditions of conventional peptide synthesis are described. The relatively high stability of N-maleoyl-peptide derivatives in aqueous solutions at neutral or slightly acidic pH values as well as the fast addition of thiol compounds to the maleimido group indicate that these peptide derivatives are well suited for the preparation of tracers of peptide factors and of peptide-protein conjugates.
描述了一种N-马来酰基-ω-氨基酸的新合成方法、其在将马来酰亚胺基团引入肽因子中的用途以及该基团在常规肽合成标准条件下的稳定性。N-马来酰基肽衍生物在中性或略酸性pH值的水溶液中具有较高的稳定性，以及硫醇化合物能快速加成到马来酰亚胺基团上，这表明这些肽衍生物非常适合用于制备肽因子示踪剂和肽-蛋白质缀合物。
