Department of Medical Sciences: Environmental and Occupational Medicine, Uppsala University, Uppsala, Sweden.
Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden.
Respir Med. 2023 May;211:107213. doi: 10.1016/j.rmed.2023.107213. Epub 2023 Mar 16.
Previous studies on the association between abdominal and general obesity and respiratory disease have provided conflicting results.
We aimed to explore the associations of abdominal obesity with respiratory symptoms, asthma, and chronic obstructive pulmonary disease independently from general obesity in women and men.
This cross-sectional study was based on the Respiratory Health in Northern Europe (RHINE) III questionnaire (n = 12 290) conducted in 2010-2012. Abdominal obesity was self-measured waist circumference using a sex-specific standard cut-off point: ≥102 cm in males and ≥88 cm in females. General obesity was defined as self-reported BMI ≥30.0 kg/m.
There were 4261 subjects (63% women) with abdominal obesity and 1837 subjects (50% women) with general obesity. Both abdominal and general obesity was independent of each other and associated with respiratory symptoms (odds ratio (OR) from 1.25 to 2.00)). Asthma was significantly associated with abdominal and general obesity in women, OR (95% CI) 1.56 (1.30-1.87) and 1.95 (1.56-2.43), respectively, but not in men, OR 1.22 (0.97-3.17) and 1.28 (0.97-1.68) respectively. A similar sex difference was found for self-reported chronic obstructive pulmonary disease.
General and abdominal obesity were independent factors associated with respiratory symptoms in adults. Asthma and chronic obstructive pulmonary disease were independently linked to abdominal and general obesity in women but not men.
先前关于腹部肥胖和全身肥胖与呼吸疾病之间关联的研究结果相互矛盾。
我们旨在探索腹部肥胖与男性和女性的呼吸症状、哮喘和慢性阻塞性肺疾病之间的关联，而不受一般肥胖的影响。
本横断面研究基于 2010-2012 年进行的北欧呼吸健康（RHINE）III 问卷调查（n=12290）。腹部肥胖通过使用性别特异性标准截止点（男性≥102cm，女性≥88cm）自我测量腰围来定义。一般肥胖定义为自我报告的 BMI≥30.0kg/m²。
有 4261 名受试者（63%为女性）存在腹部肥胖，1837 名受试者（50%为女性）存在全身肥胖。腹部肥胖和全身肥胖相互独立，与呼吸症状相关（比值比（OR）为 1.25 至 2.00）。哮喘与女性的腹部肥胖和全身肥胖显著相关，OR（95%CI）分别为 1.56（1.30-1.87）和 1.95（1.56-2.43），但与男性无关，OR 分别为 1.22（0.97-3.17）和 1.28（0.97-1.68）。在自我报告的慢性阻塞性肺疾病中也发现了类似的性别差异。
一般肥胖和腹部肥胖是成年人呼吸症状的独立相关因素。哮喘和慢性阻塞性肺疾病与女性的腹部肥胖和全身肥胖独立相关，但与男性无关。
