在双相情感障碍中，神经连接蛋白3水平升高，且与认知状态和4-羟基壬烯醛相关。
Neurexin-3 is Elevated and Associated with Cognition Status and 4-Hydroxynonenal in Bipolar Disorder.
作者信息
Sudhakar Guguloth, Nandeesha Hanumanthappa, Menon Vikas, Saravanan Kothandan
机构信息
Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Department of Psychiatry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
出版信息
Ann Neurosci. 2025 Mar 4:09727531251322019. doi: 10.1177/09727531251322019.
BACKGROUND
Alteration in synaptic plasticity and oxidative stress is involved in the pathogenesis of bipolar disorder (BD).
PURPOSE
The objectives of the study were to analyse neurexin-3 and 4-hydroxynonenal (4-HNE) levels in BD and their relation with cognitive scores and severity of the disease.
METHODS
Eighty-four BD patients and 84 healthy volunteers were enrolled. Neurexin-3 and 4-HNE were analysed by enzyme-linked immunosorbent assay (ELISA). Cognitive scores were determined using Addenbrooke's Cognitive Examination III (ACE-III) scores.
RESULTS
4-HNE ( < .001) and neurexin-3 ( < .001) were higher in BD cases in comparison with controls. 4-HNE was positively related to neurexin-3 ( = .048). Neurexin-3 was related to the total ACE-III score ( = .029), attention ( = .040) and fluency ( = .026) scores in BD cases. When multivariate analysis was done, neurexin-3 was related to ACE-III score in BD ( = .005).
CONCLUSION
We conclude that neurexin-3 is increased and associated with 4-HNE and cognitive dysfunction in BD.
背景
突触可塑性改变和氧化应激参与双相情感障碍（BD）的发病机制。
目的
本研究旨在分析BD患者中神经纤连蛋白-3和4-羟基壬烯醛（4-HNE）水平及其与认知评分和疾病严重程度的关系。
方法
招募84例BD患者和84名健康志愿者。采用酶联免疫吸附测定（ELISA）法分析神经纤连蛋白-3和4-HNE。使用Addenbrooke认知功能测试Ⅲ（ACE-Ⅲ）评分确定认知评分。
结果
与对照组相比，BD患者的4-HNE（<.001）和神经纤连蛋白-3（<.001）水平更高。4-HNE与神经纤连蛋白-3呈正相关（=.048）。在BD患者中，神经纤连蛋白-3与ACE-Ⅲ总分（=.029）、注意力（=.040）和流畅性（=.026）评分相关。进行多变量分析时，神经纤连蛋白-3与BD患者的ACE-Ⅲ评分相关（=.005）。
结论
我们得出结论，BD患者中神经纤连蛋白-3升高，并与4-HNE和认知功能障碍相关。
Zotero 插件