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微创经皮肾镜取石术与逆行肾内手术治疗肾盂输尿管连接部上段输尿管结石的前瞻性随机对照研究

Miniperc percutaneous nephrolithotomy versus retrograde intrarenal surgery in the treatment of juxta uretero-pelvic junction upper ureteric calculi: A prospective, randomized control study.

作者信息

Koushik T P Pradhyumna, Meyyappan Vivek, Aher Nakul Baban, Sekar Hariharasudhan, Thiruvengadam Gayathri, Krishnamoorthy Sriram

机构信息

Department of Urology and Renal Transplantation, Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India.

Department of Allied Health Sciences, Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India.

出版信息

Urol Ann. 2025 Jan-Mar;17(1):9-16. doi: 10.4103/ua.ua_48_24. Epub 2025 Jan 18.

Abstract

INTRODUCTION

Treatment of upper ureteric calculi has always remained a challenge for urologists. Treating the juxta-UPJ stones has been even more challenging. Difficulties in access, the possibility of up migration of stones, higher chances of leaving behind residual fragments, and the need for ancillary procedures like ESWL or relook URS have been a few inherent limitations in treating such stones. Offering PCNL for smaller stones was considered an overkill by many urologists. However, with the advent of miniaturized PCNL and improvisations in RIRS techniques, more and more of such stones are tackled with ease.

OBJECTIVE

To compare the safety and efficacy of mini-percutaneous nephrolithotomy (Miniperc PCNL) and retrograde intrarenal surgery (RIRS) in the management of juxta pelvi-ureteric junction (PUJ) calculi, located between 1 and 2 cm from PUJ.

MATERIALS AND METHODS

A prospective, randomized study was done on 100 patients with upper ureteric stones up to 2 cm in size and within 2 cm from PUJ. Patients with odd numbers were assigned Group A (Miniperc PCNL, = 50) and even numbers were assigned to Group B (RIRS, = 50).

RESULTS

Stone-free rates were 92% for Group A and 72% for Group B ( < 0.0174). Mean operative time was significantly shorter in Group A than Group B (53.2 min vs. 68.52 min, < 0.001). Hospital stay was longer for Group A (47.42 h) compared to Group B (29.36 h, < 0.001). Lasing time was more with RIRS than with PCNL (10.18 min vs. 3.24 min, < 0.001). The complications were more in Group A than Group B, but not significant ( = 0.160). Postoperative pain and time to return to normal activities were significantly better in Group B RIRS ( < 0.001).

CONCLUSIONS

Both Miniperc PCNL and RIRS are the effective treatments for upper ureteric stones. Miniperc PCNL has advantages in terms of shorter operative time, lesser lasing time, and better stone free rates. RIRS demonstrated reduced hospital stay, reduced postoperative pain, and quicker recovery. Miniperc PCNL showed a higher stone-free rate for treating upper ureteric stones up to 2 cm. RIRS is effective for treating stones up to 2 cm in upper ureter reducing the complications associated with Miniperc PCNL.

摘要

引言

上输尿管结石的治疗一直是泌尿外科医生面临的挑战。治疗肾盂输尿管连接部(UPJ)附近的结石更具挑战性。手术入路困难、结石上移的可能性、残留碎片遗留的几率较高,以及需要诸如体外冲击波碎石术(ESWL)或再次输尿管软镜检查(URS)等辅助程序,这些都是治疗此类结石的一些固有局限性。对于较小的结石采用经皮肾镜取石术(PCNL)被许多泌尿外科医生认为是小题大做。然而,随着小型化PCNL的出现以及逆行肾内手术(RIRS)技术的改进,越来越多此类结石得以轻松处理。

目的

比较微创经皮肾镜取石术(Miniperc PCNL)和逆行肾内手术(RIRS)在处理距离肾盂输尿管连接部(PUJ)1至2厘米的肾盂输尿管连接部(PUJ)结石中的安全性和有效性。

材料与方法

对100例大小达2厘米且距离PUJ在2厘米以内的上输尿管结石患者进行了一项前瞻性随机研究。奇数患者被分配到A组(Miniperc PCNL,n = 50),偶数患者被分配到B组(RIRS,n = 50)。

结果

A组结石清除率为92%,B组为72%(P < 0.0174)。A组平均手术时间明显短于B组(53.2分钟对68.52分钟,P < 0.001)。A组住院时间比B组长(47.42小时对29.36小时,P < 0.001)。RIRS的激光碎石时间比PCNL长(10.18分钟对3.24分钟,P < 0.001)。A组并发症比B组多,但差异无统计学意义(P = 0.160)。B组RIRS术后疼痛及恢复正常活动的时间明显更好(P < 0.001)。

结论

Miniperc PCNL和RIRS都是治疗上输尿管结石的有效方法。Miniperc PCNL在手术时间短、激光碎石时间短和结石清除率更好方面具有优势。RIRS表现为住院时间缩短、术后疼痛减轻和恢复更快。Miniperc PCNL在治疗大小达2厘米的上输尿管结石时结石清除率更高。RIRS对于治疗上输尿管中大小达2厘米的结石有效,可减少与Miniperc PCNL相关的并发症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f071/11881950/1988d4e64843/UA-17-9-g001.jpg

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