Key Laboratory of Head & Neck Cancer Translational Research of Zhejiang Province, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, No. 1, Banshan east road, Gongshu district, Hangzhou, Zhejiang, China; Wenzhou Medical University, Wenzhou, Zhejiang, China.
Key Laboratory of Head & Neck Cancer Translational Research of Zhejiang Province, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, No. 1, Banshan east road, Gongshu district, Hangzhou, Zhejiang, China.
Phytomedicine. 2024 Dec;135:156003. doi: 10.1016/j.phymed.2024.156003. Epub 2024 Sep 8.
Gastric cancer (GC) ranks as the fifth most prevalent malignancy worldwide. Conventional treatments, including radiotherapy and chemotherapy, often induce severe side effects and significant adverse reactions, and they may also result in drug resistance. Consequently, there is a critical need for the development of new therapeutic agents. Traditional Chinese Medicine (TCM) and natural products are being extensively researched due to their low toxicity, multi-targeted approaches, and diverse pathways. Scholars are increasingly focusing on identifying active anticancer components within TCM.
This review aims to summarise research conducted over the past 14 years on the treatment of GC using TCM. The focus is on therapeutic targets, mechanisms, and efficacy of Chinese medicine and natural products, including monomer compounds, extracts or analogues, and active ingredients.
Relevant articles on TCM and GC were retrieved from PubMed using appropriate keywords. The collected articles were screened and classified according to the types of TCM, with an emphasis on the molecular mechanisms underlying the treatment of GC.
The research on TCM indicates that TCM and natural products can effectively inhibit the metastasis, proliferation, and invasion of tumour cells. They can also induce apoptosis, autophagy and improve the chemosensitivity of drug-resistant cells. Additionally, injections derived from Chinese herbal medicine, when used as an adjunct to conventional chemotherapy, can significantly improve the prognosis of GC patients by reducing chemotherapy toxicity.
This review summarises the progress of TCM treatment of GC over the past 14 years, and discusses its therapeutic application of GC, which proves that TCM is a promising treatment strategy for GC in the future.
胃癌（GC）是全球第五大常见恶性肿瘤。常规治疗方法，包括放疗和化疗，常引发严重的副作用和明显的不良反应，还可能导致耐药性。因此，开发新的治疗药物迫在眉睫。由于毒性低、多靶点、多途径等特点，中药（TCM）和天然产物正受到广泛研究。学者们越来越关注从 TCM 中寻找具有抗癌活性的成分。
本综述旨在总结过去 14 年 TCM 治疗 GC 的研究。重点介绍中药和天然产物的治疗靶点、作用机制和疗效，包括单体化合物、提取物或类似物以及活性成分。
使用适当的关键词从 PubMed 检索关于 TCM 和 GC 的相关文章。根据 TCM 的类型对收集到的文章进行筛选和分类，重点关注治疗 GC 的分子机制。
TCM 的研究表明，TCM 和天然产物可以有效抑制肿瘤细胞的转移、增殖和侵袭。它们还可以诱导细胞凋亡、自噬，并提高耐药细胞的化疗敏感性。此外，中草药注射液与常规化疗联合使用时，可通过降低化疗毒性，显著改善 GC 患者的预后。
本综述总结了过去 14 年 TCM 治疗 GC 的进展，并讨论了其治疗 GC 的应用，证明 TCM 是未来 GC 治疗的一种有前途的治疗策略。
