Svennerholm L
Biochim Biophys Acta. 1985 Jul 9;835(2):231-5. doi: 10.1016/0005-2760(85)90277-2.
The ganglioside composition of adult human thyroid gland was examined in autopsy material obtained from patients who died of circulatory diseases but who showed no signs of thyroid disorders. The concentrations of phospholipids, cholesterol and gangliosides (lipid-bound sialic acid) in the whole glands were 5.2, 4.3 and 0.12 mmol/kg fresh tissue weight and, in dissected follicular material, 7.0, 3.4 and 0.24 mmol/kg tissue, respectively. The molar ratio of phospholipids/cholesterol/gangliosides in the follicular material was 1.00:0.49:0.034. Twelve molecular species of gangliosides were isolated and identified. Gangliosides GM3 and GD3 were most abundant, but GD1a, GD1b, GT1b and 3'-LM1 were also present in quantities greater than 5% of the total gangliosides. N-Acetylneuraminic acid and an alkali labile sialic acid, probably N-acetyl-9-O-acetylneuraminic acid, were found to occur in human thyroid.
对死于循环系统疾病但无甲状腺疾病迹象的患者尸检材料中的成人人类甲状腺神经节苷脂成分进行了检查。整个腺体中磷脂、胆固醇和神经节苷脂（脂质结合唾液酸）的浓度分别为5.2、4.3和0.12 mmol/kg新鲜组织重量，在分离的滤泡物质中分别为7.0、3.4和0.24 mmol/kg组织。滤泡物质中磷脂/胆固醇/神经节苷脂的摩尔比为1.00:0.49:0.034。分离并鉴定了12种神经节苷脂分子种类。神经节苷脂GM3和GD3最为丰富，但GD1a、GD1b、GT1b和3'-LM1的含量也超过总神经节苷脂的5%。发现N-乙酰神经氨酸和一种碱不稳定唾液酸，可能是N-乙酰-9-O-乙酰神经氨酸，存在于人类甲状腺中。
