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与潜在癫痫发作障碍相关的体位性窒息导致的死亡。

Death due to positional asphyxia related to underlying seizure disorder.

作者信息

Yu Garlen, Prahlow Joseph A

机构信息

Department of Pediatrics, Kaiser Permanente, San Diego, CA, USA.

Department of Pathology, St. Louis University School of Medicine, Office of the Medical Examiner- City of St. Louis, St. Louis, MO, USA.

出版信息

Forensic Sci Med Pathol. 2025 Mar 7. doi: 10.1007/s12024-025-00973-1.

DOI:10.1007/s12024-025-00973-1
PMID:40053201
Abstract

Positional asphyxia occurs when a victim fails to remove themself from a compromising position, leading to the restriction of respiration with subsequent death. Many cases involve an inverted body position with or without abnormal kinking of the neck. Victims are typically unable to recover from dangerous situations due to impaired consciousness. Furthermore, positional asphyxia is often accidental, stemming from conditions such as intoxication and varying neurologic disorders. We report a unique case of a death of a college student due to positional asphyxia related to an underlying seizure disorder to highlight the significant dangers that individuals face with seizure disorders, including sudden unexplained death in epilepsy (SUDEP).

摘要

当受害者无法自行脱离危及呼吸的体位时,就会发生体位性窒息,进而导致呼吸受限并最终死亡。许多案例涉及身体倒置的体位,颈部可能伴有或不伴有异常扭曲。由于意识受损,受害者通常无法从危险处境中恢复过来。此外,体位性窒息往往是意外发生的,起因于诸如中毒和各种神经系统疾病等情况。我们报告了一例独特的案例,一名大学生因与潜在癫痫发作障碍相关的体位性窒息死亡,以强调癫痫发作障碍患者所面临的重大危险,包括癫痫猝死(SUDEP)。

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本文引用的文献

1
The analysis of SUDEP forensic autopsies leading to preventable events.对导致可预防事件的癫痫性猝死法医尸检的分析。
Front Neurol. 2023 Jun 29;14:1231515. doi: 10.3389/fneur.2023.1231515. eCollection 2023.
2
A qualitative study of the reactions of young adults with epilepsy to SUDEP disclosure, perceptions of risks, views on the timing of disclosure, and behavioural change.一项关于癫痫青年成人对不明原因癫痫性猝死信息披露的反应、风险认知、信息披露时机看法及行为改变的定性研究。
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A systematic review and meta-analysis of heart rate variability in epilepsy and antiepileptic drugs.
癫痫与抗癫痫药物治疗中心率变异性的系统评价和荟萃分析。
Epilepsia. 2012 Feb;53(2):272-82. doi: 10.1111/j.1528-1167.2011.03361.x. Epub 2012 Jan 5.
4
Accidents and injuries in patients with epilepsy.癫痫患者的事故与损伤
Expert Rev Neurother. 2009 Feb;9(2):291-8. doi: 10.1586/14737175.9.2.291.
5
Conditions and circumstances predisposing to death from positional asphyxia in adults.成人因体位性窒息致死的诱发条件和情况。
J Forensic Leg Med. 2008 Oct;15(7):415-9. doi: 10.1016/j.jflm.2008.01.001. Epub 2008 Mar 10.
6
Antiepileptic drugs--best practice guidelines for therapeutic drug monitoring: a position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies.抗癫痫药物——治疗药物监测的最佳实践指南:国际抗癫痫联盟治疗策略委员会治疗药物监测小组委员会的立场文件
Epilepsia. 2008 Jul;49(7):1239-76. doi: 10.1111/j.1528-1167.2008.01561.x.
7
Sudden unexpected death in epilepsy patients: Risk factors. A systematic review.癫痫患者的意外猝死:危险因素。一项系统综述。
Seizure. 2007 Jan;16(1):1-7. doi: 10.1016/j.seizure.2006.10.002. Epub 2006 Nov 28.
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Epilepsy-related injuries.癫痫相关损伤
Epilepsia. 2006;47 Suppl 1:79-86. doi: 10.1111/j.1528-1167.2006.00666.x.
9
Variability of antiepileptic medication taking behaviour in sudden unexplained death in epilepsy: hair analysis at autopsy.癫痫性猝死中抗癫痫药物服用行为的变异性:尸检时的毛发分析
J Neurol Neurosurg Psychiatry. 2006 Apr;77(4):481-4. doi: 10.1136/jnnp.2005.067777.
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Sudden unexpected death in epilepsy: evidence-based analysis of incidence and risk factors.癫痫猝死:发病率及危险因素的循证分析
Epilepsy Res. 2005 Jun;65(1-2):101-15. doi: 10.1016/j.eplepsyres.2005.05.004.