CZT-based photon-counting-detector CT with deep-learning reconstruction: image quality and diagnostic confidence for lung tumor assessment.

PURPOSE

This is a preliminary analysis of one of the secondary endpoints in the prospective study cohort. The aim of this study is to assess the image quality and diagnostic confidence for lung cancer of CT images generated by using cadmium-zinc-telluride (CZT)-based photon-counting-detector-CT (PCD-CT) and comparing these super-high-resolution (SHR) images with conventional normal-resolution (NR) CT images.

MATERIALS AND METHODS

Twenty-five patients (median age 75 years, interquartile range 66-78 years, 18 men and 7 women) with 29 lung nodules overall (including two patients with 4 and 2 nodules, respectively) were enrolled to undergo PCD-CT. Three types of images were reconstructed: a 512 × 512 matrix with adaptive iterative dose reduction 3D (AIDR 3D) as the NR image, a 1024 × 1024 matrix with AIDR 3D as the SHR image, and a 1024 × 1024 matrix with deep-learning reconstruction (DLR) as the SHR image. For qualitative analysis, two radiologists evaluated the matched reconstructed series twice (NR vs. SHR and SHR vs. SHR) and scored the presence of imaging findings, such as spiculation, lobulation, appearance of ground-glass opacity or air bronchiologram, image quality, and diagnostic confidence, using a 5-point Likert scale. For quantitative analysis, contrast-to-noise ratios (CNRs) of the three images were compared.

RESULTS

In the qualitative analysis, compared to NR, SHR yielded higher image quality and diagnostic confidence, except for image noise (all P < 0.01). In comparison with SHR, SHR yielded higher image quality and diagnostic confidence (all P < 0.01). In the quantitative analysis, CNRs in the modified NR and SHR groups were higher than those in the SHR group (P = 0.003, <0.001, respectively).

CONCLUSION

In PCD-CT, SHR images provided the highest image quality and diagnostic confidence for lung tumor evaluation, followed by SHR and NR images. DLR demonstrated superior noise reduction compared to other reconstruction methods.