Rai K, Van Ryzin J
Biometrics. 1985 Mar;41(1):1-9.
This paper introduces a dose-response model for teratological quantal response data where the probability of response for an offspring from a female at a given dose varies with the litter size. The maximum likelihood estimators for the parameters of the model are given as the solution of a nonlinear iterative algorithm. Two methods of low-dose extrapolation are presented, one based on the litter size distribution and the other a conservative method. The resulting procedures are then applied to a teratological data set from the literature.
本文介绍了一种针对致畸学定量反应数据的剂量反应模型，其中给定剂量下雌性后代的反应概率随窝仔数而变化。该模型参数的最大似然估计值通过非线性迭代算法的解给出。提出了两种低剂量外推方法，一种基于窝仔数分布，另一种是保守方法。然后将所得程序应用于文献中的一个致畸学数据集。
