[不同程度表现的心肌损伤建模]
[Modeling of myocardial lesions of varying degrees of manifestation].
作者信息
Reznikov K M, Leonov A N, Kitaeva R I, Bykov E G, Provotorova P P
出版信息
Biull Eksp Biol Med. 1985 May;99(5):532-4.
PMID:4005403
Abstract
Five variants of myocardial lesions of different degree were simulated in experiments on 8 dogs, 61 rabbits and 30 rats, namely micronecrosis, diffuse myocarditis, focal dystrophy, small- and large-focal myocardial infarction. The experimental models of heart lesions can be used for studying the pathophysiological mechanisms in cardiac pathology and evaluation of the therapeutic efficacy of new drugs in experimental pharmacology.
摘要
在对8只犬、61只兔和30只大鼠进行的实验中，模拟了5种不同程度的心肌损伤变体，即微坏死、弥漫性心肌炎、局灶性营养不良、小灶性和大灶性心肌梗死。心脏损伤的实验模型可用于研究心脏病理学中的病理生理机制以及评估实验药理学中新药的治疗效果。
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