Potentiation of morphine analgesia by caffeine.
作者信息
Misra A L, Pontani R B, Vadlamani N L
出版信息
Br J Pharmacol. 1985 Apr;84(4):789-91. doi: 10.1111/j.1476-5381.1985.tb17372.x.
Abstract
Significant potentiation of morphine (5 mg kg-1 s.c. or 1 mg kg-1 i.v.) analgesia (tail-withdrawal reflex at 55 degrees C) was observed in caffeine-treated (100 mg kg-1 i.p.) rats as compared to the control group and lower doses of caffeine (2mg kg-1 i.p.) did not show this effect. Potentiated analgesia was reversed by naloxone. Pharmacokinetic or dispositional factors appear to be involved in part in this potentiation.
摘要
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1
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J Biol Chem. 1962 Apr;237:1244-50.
2
Unit activity in medial thalamus: comparative effects of caffeine an amphetamine.
J Pharmacol Exp Ther. 1980 Jun;213(3):580-5.
3
Caffeine as an analgesic adjuvant.
JAMA. 1984 Apr 6;251(13):1711-8.
4
Caffeine stimulates beta-endorphin release in blood but not in cerebrospinal fluid.
Life Sci. 1982 Sep 6;31(10):1017-24. doi: 10.1016/0024-3205(82)90174-6.
5
Caffeine injection raises brain tryptophan level, but does not stimulate the rate of serotonin synthesis in rat brain.咖啡因注射可提高大鼠大脑中的色氨酸水平，但不会刺激大鼠大脑中血清素的合成速率。
Life Sci. 1984 Sep 17;35(12):1241-7. doi: 10.1016/0024-3205(84)90094-8.
6
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Life Sci. 1981 May 11;28(19):2083-97. doi: 10.1016/0024-3205(81)90614-7.
7
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8
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