Ialongo Davide, Tudino Valeria, Arpacioglu Merve, Messore Antonella, Patacchini Elisa, Costi Roberta, Di Santo Roberto, Madia Valentina Noemi
Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, p.le Aldo Moro 5, I-00185 Rome, Italy.
Pharmaceuticals (Basel). 2023 May 11;16(5):730. doi: 10.3390/ph16050730.
Plants have been known since ancient times for their healing properties, being used as preparations against human diseases of different etiologies. More recently, natural products have been studied and characterized, isolating the phytochemicals responsible for their bioactivity. Most certainly, there are currently numerous active compounds extracted from plants and used as drugs, dietary supplements, or sources of bioactive molecules that are useful in modern drug discovery. Furthermore, phytotherapeutics can modulate the clinical effects of co-administered conventional drugs. In the last few decades, the interest has increased even more in studying the positive synergistic effects between plant-derived bioactives and conventional drugs. Indeed, synergism is a process where multiple compounds act together to exert a merged effect that is greater than that of each of them summed together. The synergistic effects between phytotherapeutics and conventional drugs have been described in different therapeutic areas, and many drugs are based on synergistic interactions with plant derivatives. Among them, caffeine has shown positive synergistic effects with different conventional drugs. Indeed, in addition to their multiple pharmacological activities, a growing body of evidence highlights the synergistic effects of caffeine with different conventional drugs in various therapeutic fields. This review aims to provide an overview of the synergistic therapeutic effects of caffeine and conventional drugs, summarizing the progress reported to date.
自古以来，人们就知道植物具有治疗功效，被用作治疗不同病因人类疾病的制剂。最近，对天然产物进行了研究和表征，分离出了具有生物活性的植物化学物质。毫无疑问，目前有许多从植物中提取的活性化合物被用作药物、膳食补充剂或生物活性分子的来源，这些对现代药物研发很有用。此外，植物疗法可以调节联合使用的传统药物的临床效果。在过去几十年里，对植物源生物活性物质与传统药物之间积极协同作用的研究兴趣甚至更高了。事实上，协同作用是指多种化合物共同作用以产生大于它们各自单独作用之和的综合效应的过程。植物疗法与传统药物之间的协同作用已在不同治疗领域得到描述，许多药物都是基于与植物衍生物的协同相互作用。其中，咖啡因已显示出与不同传统药物的积极协同作用。的确，除了其多种药理活性外，越来越多的证据突出了咖啡因在各个治疗领域与不同传统药物的协同作用。本综述旨在概述咖啡因与传统药物的协同治疗作用，总结迄今报道的进展。
