Zhang Zihan, Liu Yi, Yu Tian, Liu Zhen
The State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
The State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China,
J Innate Immun. 2025;17(1):211-225. doi: 10.1159/000542531. Epub 2025 Mar 7.
Periodontitis is recognized as one of the most prevalent oral dysbiotic inflammatory diseases, ultimately leading to the irreversible destruction of periodontal tissues. Macrophages play a pivotal role in the development and progression of periodontitis, and the feasibility of targeting them therapeutically has been established. Since metabolic switching significantly contributes to macrophage regulation, conducting an in-depth review of macrophage metabolism in periodontitis may serve as the foundation for developing innovative treatments.
This paper has been carefully reviewed to provide a comprehensive overview of the roles played by macrophages in periodontitis and associated comorbidities. Initially, detailed presentations on the metabolic reprogramming of macrophages, including glucose, lipid, and amino acid metabolism, were provided. Subsequently, dominating macrophage phenotype and metabolism under lipopolysaccharide (LPS) stimulation or during periodontitis were presented with emphasize on critical molecules involved. Furthermore, in recognition of the close association between periodontitis and several comorbidities, the interaction among macrophage metabolism, periodontitis, and related metabolic diseases, was thoroughly discussed.
Through the examination of current research on macrophage metabolic reprogramming induced by periodontitis, this review provides potential immunometabolic therapeutic targets for the future and raises many important, yet unstudied, subjects for follow-up.
Periodontitis is recognized as one of the most prevalent oral dysbiotic inflammatory diseases, ultimately leading to the irreversible destruction of periodontal tissues. Macrophages play a pivotal role in the development and progression of periodontitis, and the feasibility of targeting them therapeutically has been established. Since metabolic switching significantly contributes to macrophage regulation, conducting an in-depth review of macrophage metabolism in periodontitis may serve as the foundation for developing innovative treatments.
This paper has been carefully reviewed to provide a comprehensive overview of the roles played by macrophages in periodontitis and associated comorbidities. Initially, detailed presentations on the metabolic reprogramming of macrophages, including glucose, lipid, and amino acid metabolism, were provided. Subsequently, dominating macrophage phenotype and metabolism under lipopolysaccharide (LPS) stimulation or during periodontitis were presented with emphasize on critical molecules involved. Furthermore, in recognition of the close association between periodontitis and several comorbidities, the interaction among macrophage metabolism, periodontitis, and related metabolic diseases, was thoroughly discussed.
Through the examination of current research on macrophage metabolic reprogramming induced by periodontitis, this review provides potential immunometabolic therapeutic targets for the future and raises many important, yet unstudied, subjects for follow-up.
牙周炎被认为是最常见的口腔生态失调性炎症性疾病之一，最终会导致牙周组织的不可逆破坏。巨噬细胞在牙周炎的发生和发展中起关键作用，并且已经确定了针对它们进行治疗的可行性。由于代谢转换对巨噬细胞调节有显著贡献，深入综述牙周炎中巨噬细胞的代谢情况可能为开发创新治疗方法奠定基础。
本文经过仔细审阅，全面概述了巨噬细胞在牙周炎及相关合并症中所起的作用。首先，详细介绍了巨噬细胞的代谢重编程，包括葡萄糖、脂质和氨基酸代谢。随后，阐述了脂多糖（LPS）刺激下或牙周炎期间占主导地位的巨噬细胞表型和代谢，并强调了相关关键分子。此外，鉴于牙周炎与几种合并症之间的密切关联，还深入讨论了巨噬细胞代谢、牙周炎和相关代谢疾病之间的相互作用。
通过审视目前关于牙周炎诱导的巨噬细胞代谢重编程的研究，本综述为未来提供了潜在的免疫代谢治疗靶点，并提出了许多重要但尚未研究的后续课题。
牙周炎被认为是最常见的口腔生态失调性炎症性疾病之一，最终会导致牙周组织的不可逆破坏。巨噬细胞在牙周炎的发生和发展中起关键作用，并且已经确定了针对它们进行治疗的可行性。由于代谢转换对巨噬细胞调节有显著贡献，深入综述牙周炎中巨噬细胞的代谢情况可能为开发创新治疗方法奠定基础。
本文经过仔细审阅，全面概述了巨噬细胞在牙周炎及相关合并症中所起的作用。首先，详细介绍了巨噬细胞的代谢重编程，包括葡萄糖、脂质和氨基酸代谢。随后，阐述了脂多糖（LPS）刺激下或牙周炎期间占主导地位的巨噬细胞表型和代谢，并强调了相关关键分子。此外，鉴于牙周炎与几种合并症之间的密切关联，还深入讨论了巨噬细胞代谢、牙周炎和相关代谢疾病之间的相互作用。
通过审视目前关于牙周炎诱导的巨噬细胞代谢重编程的研究，本综述为未来提供了潜在的免疫代谢治疗靶点，并提出了许多重要但尚未研究的后续课题。
