Luo Zhangyi, Chen Chien-Yu, Li Song
Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Small Methods. 2025 Mar 9:e2401860. doi: 10.1002/smtd.202401860.
Recent advances in the development of tumor-targeting nanoparticles (NPs) significantly enhance cancer therapies by effectively increasing the therapeutic window of drugs, improving the response of tumor cells, and augmenting anti-tumor immunity. However, the understanding of the tumor-targeting process remains elusive because of the complex in vivo behavior of nanoparticles. Various factors are reported to alter this process; however, systematic studies on tumor-targeting mechanisms remain limited. In this review, an overview of current strategies for improving tumor targeting and their applications in cancer chemotherapy and immunotherapy, with a focus on the advancement of the understanding of various in vivo barriers for effective tumor targeting and penetration is provided.
肿瘤靶向纳米颗粒（NPs）开发的最新进展通过有效扩大药物治疗窗口、改善肿瘤细胞反应以及增强抗肿瘤免疫力，显著提升了癌症治疗效果。然而，由于纳米颗粒在体内的行为复杂，对肿瘤靶向过程的理解仍然难以捉摸。据报道，多种因素会改变这一过程；然而，关于肿瘤靶向机制的系统性研究仍然有限。在本综述中，我们概述了当前改善肿瘤靶向的策略及其在癌症化疗和免疫治疗中的应用，重点是增进对有效肿瘤靶向和渗透的各种体内屏障的理解。
