Valente Denise, Vienola Kari V, Zawadzki Robert J, Jonnal Ravi S
Center for Human Ophthalmic Imaging Research (CHOIR), University of California, Davis Eye Center, 95817 Sacramento CA, USA.
Fisica de Materiais, Escola Politecnica de Pernambuco, Universidade de Pernambuco, 50720-001 Recife PE, Brazil.
bioRxiv. 2025 Feb 28:2025.02.28.639986. doi: 10.1101/2025.02.28.639986.
Optoretinography is an emerging method for detecting and measuring functional responses from neurons in the living human retina. Its potential applications are significant and broad, spanning clinical assessment of retinal disease, investigation of fundamental scientific questions, and rapid evaluation of experimental therapeutics for blinding retinal diseases. Progress in all these domains hinges on the development of robust methods for quantifying observed responses in relation to visible stimuli. In this work, we describe a novel optoretinographic imaging platform-full-field swept-source optical coherence tomography with adaptive optics, measure cone responses in two healthy volunteers to a variety of stimulus patterns, and propose a simple model for predicting and quantifying responses to those stimuli.
视网膜电图是一种新兴的用于检测和测量活人视网膜中神经元功能反应的方法。其潜在应用意义重大且广泛，涵盖视网膜疾病的临床评估、基础科学问题的研究以及致盲性视网膜疾病实验治疗方法的快速评估。所有这些领域的进展都取决于开发出强大的方法来量化与可见刺激相关的观察到的反应。在这项工作中，我们描述了一种新型的视网膜电图成像平台——具有自适应光学的全视野扫频光学相干断层扫描，测量了两名健康志愿者对各种刺激模式的视锥细胞反应，并提出了一个简单模型来预测和量化对这些刺激的反应。
