Miglietta A, Bonelli G, Vironda N, Gabriel L
Cell Biochem Funct. 1985 Jan;3(1):9-11. doi: 10.1002/cbf.290030104.
Methylglyoxal inhibits cell division, exerting an antiproliferative action on tumour cells. Supernatants from ascites hepatoma cell homogenate, previously incubated with the aldehyde, showed a decrease in colchicine binding activity dependent on methylglyoxal concentration. In contrast, in vivo treatment of tumour-bearing rats apparently did not cause a significant impairment of microtubular protein, suggesting that the aldehyde interaction with microtubules cannot be considered responsible for its carcinostatic action.
甲基乙二醛可抑制细胞分裂，对肿瘤细胞发挥抗增殖作用。预先用该醛孵育过的腹水肝癌细胞匀浆的上清液显示，秋水仙碱结合活性随甲基乙二醛浓度的增加而降低。相比之下，对荷瘤大鼠进行体内治疗显然并未导致微管蛋白出现明显损伤，这表明该醛与微管的相互作用不能被认为是其抗癌作用的原因。
