Wang Sai, Wang Keyu, Wang Xiu
Department of Thoracic Surgery, Jining Third People's Hospital (Yanzhou District People's Hospital of Jining City), Jining, China.
Department of Hepatobiliary Surgery, Jining Third People's Hospital (Yanzhou District People's Hospital of Jining City), Jining, China.
Front Med (Lausanne). 2025 Feb 21;12:1533507. doi: 10.3389/fmed.2025.1533507. eCollection 2025.
Biological age (BA) is regarded as a more accurate marker of aging than chronological age and is commonly used to assess associations with age-related diseases. The relationship between BA measures and the colorectal cancer (CRC) has not yet been investigated.
This study utilized data from the National Health and Nutrition Examination Survey. BA was quantified using the Klemera-Doubal method age (KDMAge) and phenotypic age (PhenoAge), based on 13 common clinical biomarkers. The prevalence of CRC across quartiles of BA indicators was compared using weighted Chi-square tests. Weighted multivariable logistic regression models were used to assess the association between BA indicators and CRC.
A total of 36,684 participants were included. The weighted prevalence of CRC showed a significant and consistent upward trend across ascending quartiles of chronological age, KDMAge, and PhenoAge, even within gender and age subgroups (all for trend < 0.05). In the total population and gender subgroups, higher quartiles of PhenoAge acceleration showed a higher weighted prevalence of CRC compared to lower quartiles ( for trend < 0.05). Accelerated PhenoAge was significantly associated with a higher prevalence of CRC (OR = 1.767, 95% CI: 1.236-2.524, = 0.002). However, accelerated PhenoAge was associated with the increased prevalence of CRC only in individuals older than 65 years (OR = 1.655, 95% CI: 1.143-2.397, = 0.008).
Biological aging are positively associated with the prevalence of CRC regardless of gender, particularly among the elderly.
生物学年龄（BA）被认为是比实际年龄更准确的衰老标志物，常用于评估与年龄相关疾病的关联。BA测量值与结直肠癌（CRC）之间的关系尚未得到研究。
本研究利用了美国国家健康与营养检查调查的数据。基于13种常见临床生物标志物，使用克莱梅拉-杜巴尔法年龄（KDMAge）和表型年龄（PhenoAge）对BA进行量化。使用加权卡方检验比较BA指标四分位数范围内CRC的患病率。采用加权多变量逻辑回归模型评估BA指标与CRC之间的关联。
共纳入36684名参与者。无论在性别和年龄亚组中，CRC的加权患病率在实际年龄、KDMAge和PhenoAge的四分位数上升过程中均呈现显著且一致的上升趋势（所有趋势P<0.05）。在总人群和性别亚组中，与较低四分位数相比，PhenoAge加速的较高四分位数显示出更高的CRC加权患病率（趋势P<0.05）。加速的PhenoAge与CRC的较高患病率显著相关（OR=1.767，95%CI：1.236-2.524，P=0.002）。然而，加速的PhenoAge仅在65岁以上个体中与CRC患病率增加相关（OR=1.655，95%CI：1.143-2.397，P=0.008）。
无论性别如何，生物学衰老与CRC患病率呈正相关，尤其是在老年人中。
