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无论是否进行冠状动脉内膜切除术,采用覆盖移植术均可维持长期良好的吻合口重塑,而与所使用的移植材料无关。

Onlay grafting with or without coronary endarterectomy maintains long-term favorable anastomotic remodeling regardless of the graft materials used.

作者信息

Minato Naoki, Okada Takayuki, Uetsuki Tomohiko, Kuwauchi Shintaro, Kanemoto Shinya, Zempo Nobuya, Kawaura Takayuki, Kitawaki Tomoki

机构信息

Department of Cardiovascular Surgery, Kansai Medical University, Osaka, Japan.

Department of Mathematics, Kansai Medical University, Osaka, Japan.

出版信息

JTCVS Open. 2024 Nov 26;23:157-170. doi: 10.1016/j.xjon.2024.11.007. eCollection 2025 Feb.

Abstract

OBJECTIVE

We aimed to examine the long-term clinical outcomes, graft patency, and remodeling capacities of onlay anastomoses using 4 different grafts.

METHODS

The cross-sectional areas of onlay anastomoses were measured using coronary angiography or computed tomography and compared with the estimated standard areas of normal arteries to assess changes in the onlay anastomosis area over time.

RESULTS

One hundred eight patients underwent onlay grafting (with coronary endarterectomy: 43 arteries; without: 84). The operative mortality rate was 1.85%, and the average follow-up period was 102.8 ± 52.4 months (range, 6-217 months). The reintervention-free rate was 99.2%, and late death occurred in 30 patients, including 6 cardiac deaths. The estimated survival rates were 93.6%, 79.0%, 71.3%, 56.1%, and 48.1% at 1, 5, 10, 14, and 18 years, respectively. Early angiography in 93 patients resulted in a 98.1% patency rate. Follow-up angiography on 78 patients showed a distant patency rate of 96.6% at an average of 52.7 ± 42.5 months (range, 6-180 months). Early enlargement of the onlay anastomosis reduced its size to match the native standard lumen long-term, regardless of the graft material used.

CONCLUSIONS

Onlay grafting, with or without endarterectomy, maintained anastomotic patency with major branch preservation and favorable long-term remodeling of the anastomoses, leading to luminal equalization and smoothing.

摘要

目的

我们旨在研究使用4种不同移植物进行补片吻合术的长期临床结果、移植物通畅率和重塑能力。

方法

使用冠状动脉造影或计算机断层扫描测量补片吻合术的横截面积,并与正常动脉的估计标准面积进行比较,以评估补片吻合术面积随时间的变化。

结果

108例患者接受了补片移植术(行冠状动脉内膜切除术:43条动脉;未行:84条)。手术死亡率为1.85%,平均随访期为102.8±52.4个月(范围6 - 217个月)。无再次干预率为99.2%,30例患者发生晚期死亡,其中包括6例心源性死亡。1年、5年、10年、14年和18年的估计生存率分别为93.6%、79.0%、71.3%、56.1%和48.1%。93例患者的早期血管造影显示通畅率为98.1%。对78例患者的随访血管造影显示,平均52.7±42.5个月(范围6 - 180个月)时的远期通畅率为96.6%。补片吻合术的早期扩大使其大小在长期内缩小以匹配天然标准管腔,无论使用何种移植物材料。

结论

无论是否行内膜切除术,补片移植术均能维持吻合口通畅,保留主要分支,并使吻合口长期重塑良好,从而实现管腔均等化和平滑化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b169/11883697/a2efcfe244d7/fx1.jpg

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