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龋齿管理对接受抗逆转录病毒治疗的围产期感染艾滋病毒/艾滋病儿童白色念珠菌携带情况及口腔健康相关生活质量的影响——一项实验前后研究

Effect of Dental Caries Management on the Candida Albicans Carriage and Oral Health-Related Quality of Life in Children Living With Perinatal HIV/AIDS Under Antiretroviral Therapy-A Pre- and Post-Experimental Study.

作者信息

Gurupriya M Monica, Barathi K Divya, Nalankilli Ashok Viswanath, Megalaa N, Jayaraj Merlin, Kumar P D Madan, Nagappan Nagappan

机构信息

Department of Public Health Dentistry, Sri Venkateswara Dental College and Hospital, Chennai, Tamil Nadu, India.

Department of Pediatric and Preventive Dentistry, Mahatma Gandhi Post Graduate Institute of Dental Sciences, Puducherry, India.

出版信息

J Pharm Bioallied Sci. 2024 Dec;16(Suppl 5):S4445-S4447. doi: 10.4103/jpbs.jpbs_917_24. Epub 2025 Jan 30.

DOI:10.4103/jpbs.jpbs_917_24
PMID:40061664
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11888755/
Abstract

BACKGROUND

Children living with perinatal HIV/AIDS (CLWPHA) have a higher prevalence of dental caries and fungal infections. Caries tooth serves as a niche for Candida colonization and it also impairs oral health-related quality of life. The management of dental caries can eliminate the risk factor for Candida colonization and subsequently can promote their quality of life related to oral health.

AIM

The aim of our study was to determine the effect of dental caries management on the carriage and oral health-related quality of life among CLWPHA under highly active antiretroviral therapy (HAART).

METHODOLOGY

This pre- and post-experimental study was conducted with 40 students. Candida colonization was assessed from the participant's saliva samples. OHRQoL of participants was assessed using the Oral Health Impact Profile-14 questionnaire.

RESULTS

The mean value of CFUs in saliva after dental caries management was significantly lower compared with before dental caries management. The mean OHIP-14 score after dental caries management was significantly lower compared with the baseline score.

CONCLUSION

Dental caries management can be effective in reducing the oral Candidal colony count, thereby improving their oral health-related quality of life.

摘要

背景

感染围产期艾滋病毒/艾滋病的儿童（CLWPHA）患龋齿和真菌感染的几率更高。龋齿是念珠菌定植的温床，还会损害口腔健康相关的生活质量。龋齿的治疗可以消除念珠菌定植的风险因素，进而提高他们与口腔健康相关的生活质量。

目的

我们研究的目的是确定在高效抗逆转录病毒疗法（HAART）下，龋齿治疗对CLWPHA的念珠菌携带情况及与口腔健康相关的生活质量的影响。

方法

这项前后对照实验研究对40名学生进行。从参与者的唾液样本中评估念珠菌定植情况。使用口腔健康影响程度量表-14问卷评估参与者的口腔健康相关生活质量。

结果

龋齿治疗后唾液中的菌落形成单位（CFU）平均值显著低于龋齿治疗前。龋齿治疗后的口腔健康影响程度量表-14（OHIP-14）平均得分显著低于基线得分。

结论

龋齿治疗可有效减少口腔念珠菌菌落计数，从而改善他们与口腔健康相关的生活质量。

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本文引用的文献

1
In vitro effects of commercial mouthwashes on several virulence traits of Candida albicans, viridans streptococci and Enterococcus faecalis colonizing the oral cavity.体外研究商业漱口水对几种口腔定植的白色念珠菌、草绿色链球菌和粪肠球菌毒力特性的影响。
PLoS One. 2018 Nov 15;13(11):e0207262. doi: 10.1371/journal.pone.0207262. eCollection 2018.
2
Quantity of Candida Colonies in Saliva: 
A Diagnostic Evaluation for Oral Candidiasis.唾液中念珠菌菌落数量：口腔念珠菌病的诊断评估
Chin J Dent Res. 2017;20(1):27-32. doi: 10.3290/j.cjdr.a37739.
3
Oral health status and its impact on the quality of life of children and adolescents living with HIV-1.口腔健康状况及其对感染HIV-1的儿童和青少年生活质量的影响。
BMC Res Notes. 2014 Jul 28;7:478. doi: 10.1186/1756-0500-7-478.
4
Changes in Candida spp., mutans streptococci and lactobacilli following treatment of early childhood caries: a 1-year follow-up.幼儿龋齿治疗后念珠菌属、变形链球菌和乳酸菌的变化：1年随访
Caries Res. 2014;48(1):24-31. doi: 10.1159/000351673. Epub 2013 Nov 6.
5
Changes in young children's OHRQoL after dental treatment under general anaesthesia.全麻下儿童牙科治疗后口腔健康相关生活质量的变化。
Int J Paediatr Dent. 2012 Jul;22(4):258-64. doi: 10.1111/j.1365-263X.2011.01190.x. Epub 2011 Oct 17.
6
Treatment and disease progression in a birth cohort of vertically HIV-1 infected children in Ukraine.在乌克兰，对垂直感染 HIV-1 的出生队列儿童的治疗和疾病进展情况。
BMC Pediatr. 2010 Nov 23;10:85. doi: 10.1186/1471-2431-10-85.
7
Reduction of Candida species colonization in the oral cavity of children infected with human immunodeficiency virus after dental treatment.牙科治疗后感染人类免疫缺陷病毒的儿童口腔念珠菌属定植的减少
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Sep;108(3):383-8. doi: 10.1016/j.tripleo.2009.04.038.
8
Oral Candida isolates colonizing or infecting human immunodeficiency virus-infected and healthy persons in Mexico.在墨西哥，定殖于或感染人类免疫缺陷病毒感染者及健康人的口腔念珠菌分离株。
J Clin Microbiol. 2005 Aug;43(8):4159-62. doi: 10.1128/JCM.43.8.4159-4162.2005.
9
Candidal carriage in the oral cavity of human immunodeficiency virus-infected subjects.人类免疫缺陷病毒感染受试者口腔中的念珠菌携带情况。
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002 Mar;93(3):281-6. doi: 10.1067/moe.2002.120804.
10
Effect of dental treatment and/or local application of amphotericin B to carious teeth on oral colonization by Candida.牙科治疗和/或将两性霉素B局部应用于龋齿对口腔念珠菌定植的影响。
Med Mycol. 1999 Oct;37(5):345-50. doi: 10.1046/j.1365-280x.1999.00242.x.