Sziegoleit F, Sziegoleit A, Wetzel W E
Department of Pediatric Dentistry, Medical Center of Odontology, Justus Liebig University of Giessen, Germany.
Med Mycol. 1999 Oct;37(5):345-50. doi: 10.1046/j.1365-280x.1999.00242.x.
Microbiological analyses of saliva and swabs were obtained from carious lesions of 54 children and adolescents with carious teeth, and of 49 boys and girls with healthy teeth. Candida species were isolated from the saliva of 36 (66.7%) subjects with active caries, but from the saliva of only one (2%) of the 49 caries-free subjects. Candida was detected in material removed from the carious lesion in 44 (81.5%) of the children with caries. Thirty patients with carious teeth and colonized by Candida were randomly divided into three groups of 10 individuals each, and either treated by complete dental restoration, by local application of amphotericin B or by a combination of dental treatment plus amphotericin B. The final microbiological control showed that thorough dental treatment alone eliminated fungi from the oral cavity in 90% of cases, whereas the local application of amphotericin B alone had a minimal effect on the candidal colonization of carious lesions. When, in addition to dental treatment, amphotericin B was applied, fungi were completely eliminated from the oral cavity of all subjects.
对54名患有龋齿的儿童和青少年以及49名牙齿健康的男孩和女孩的龋损部位进行了唾液和拭子的微生物学分析。在36名（66.7%）患有活动性龋齿的受试者的唾液中分离出念珠菌属，但在49名无龋受试者中，只有1名（2%）的唾液中分离出念珠菌。在44名（81.5%）患龋儿童的龋损部位取材中检测到念珠菌。30名患有龋齿且口腔中定植有念珠菌的患者被随机分为三组，每组10人，分别接受全口牙齿修复治疗、局部应用两性霉素B或牙齿治疗加两性霉素B联合治疗。最终的微生物学检查表明，单纯彻底的牙齿治疗在90%的病例中可清除口腔中的真菌，而单独局部应用两性霉素B对龋损部位的念珠菌定植影响极小。当除牙齿治疗外还应用两性霉素B时，所有受试者口腔中的真菌均被完全清除。
