Zhou Pei Ru, Hua Hong, Liu Xiao Song
Chin J Dent Res. 2017;20(1):27-32. doi: 10.3290/j.cjdr.a37739.
To investigate the relationship between the quantity of Candida colonies in saliva and oral candidiasis (OC), as well as to identify the threshold for distinguishing oral candidiasis from healthy carriage.
A diagnostic test was conducted in 197 patients with different oral problems. The diagnosis of OC was established based on clinical features. Whole saliva samples from the subjects were cultured for Candida species. Receiver operating characteristic (ROC) curve analysis was used in this study.
OC patients had significantly more Candida colony-forming units per millilitre saliva (795 cfu/ml) than asymptomatic carriers (40 cfu/ml; P < 0.05). Among different types of candidiasis, the quantity of Candida colonies differed. The number of Candida colonies in pseudomembranous type was significantly higher than that in the erythematous type (P < 0.05). Candida albicans was the predominant species of Candida. The cut-off point with the best fit for OC diagnosis was calculated to be 266 cfu/ml. The sensitivity and specificity were 0.720 and 0.825, respectively. Analysis of the ROC curve indicated that Candida colonies had a high diagnostic value for OC, as demonstrated by the area under the curve (AUC = 0.873).
Based on this study, the value of 270 cfu/ml was considered a threshold for distinguishing OC from carriage.
研究唾液中念珠菌菌落数量与口腔念珠菌病（OC）之间的关系，并确定区分口腔念珠菌病与健康带菌状态的阈值。
对197例有不同口腔问题的患者进行诊断测试。根据临床特征确立OC的诊断。对受试者的全唾液样本进行念珠菌属培养。本研究采用受试者工作特征（ROC）曲线分析。
OC患者每毫升唾液中的念珠菌菌落形成单位（795 cfu/ml）显著多于无症状携带者（40 cfu/ml；P<0.05）。在不同类型的念珠菌病中，念珠菌菌落数量有所不同。假膜型念珠菌菌落数量显著高于红斑型（P<0.05）。白色念珠菌是念珠菌的主要种类。计算得出最适合OC诊断的临界点为266 cfu/ml。敏感性和特异性分别为0.720和0.825。ROC曲线分析表明，念珠菌菌落对OC具有较高的诊断价值，曲线下面积（AUC=0.873）证明了这一点。
基于本研究，270 cfu/ml的值被认为是区分OC与带菌状态的阈值。
