Subramani Arulmozhi, Periasamy Panneerselvam, Gunasekaran Sasikala
Department of Physiology, JKKN Dental College and Hospital, Affiliated Under The Tamil Nadu Dr MGR Medical University, Chennai, Tamil Nadu, India.
Department of Physiology, Government Erode Medical College, Affiliated Under The Tamil Nadu Dr MGR Medical University, Chennai, Tamil Nadu, India.
J Pharm Bioallied Sci. 2024 Dec;16(Suppl 5):S4536-S4539. doi: 10.4103/jpbs.jpbs_1160_24. Epub 2025 Jan 30.
Diabetes mellitus has emerged as a global health crisis, with its prevalence escalating dramatically. Diabetic peripheral neuropathy (DPN) stands out as one of the most frequent complications, leading to significant morbidity, including foot ulcers and amputations, if not identified and managed promptly. Effective screening methods are essential for early detection, which can significantly improve patient outcomes and reduce the risk of severe complications.
This study aims to evaluate the sensitivity and specificity of the Diabetic Neuropathy Examination (DNE) score in comparison to the vibration perception threshold (VPT) test. Both methods will be assessed individually and in combination to determine their effectiveness in diagnosing DPN among patients with diabetes. The study also seeks to establish a correlation between these screening tests.
A case-control study was conducted involving 100 subjects, comprising 50 patients diagnosed with DPN and 50 healthy controls. The participants were aged between 30 and 70 years, and various parameters such as fasting blood sugar, anthropometric measurements, DNE scores, and VPT readings were recorded. Ethical clearance was obtained, and informed consent was secured from all participants.
The findings indicated that the DNE score demonstrated a sensitivity of 80% and a specificity of 73.33%, while VPT exhibited a sensitivity of 70% and a specificity of 86.67%. When both tests were combined, the sensitivity increased to 90%, highlighting the potential for enhanced diagnostic accuracy through a multimodal approach.
The DNE score, when utilized alongside VPT, provides a robust framework for the early detection of DPN, particularly in community settings where resources may be limited. This study underscores the importance of integrating simple, effective screening techniques into routine clinical practice to mitigate the risks associated with diabetic complications.
糖尿病已成为全球性的健康危机，其患病率急剧上升。糖尿病周围神经病变（DPN）是最常见的并发症之一，如果不及时识别和处理，会导致严重的发病情况，包括足部溃疡和截肢。有效的筛查方法对于早期发现至关重要，这可以显著改善患者的预后并降低严重并发症的风险。
本研究旨在评估糖尿病神经病变检查（DNE）评分与振动觉阈值（VPT）测试相比的敏感性和特异性。将分别评估这两种方法及其联合使用时在诊断糖尿病患者DPN方面的有效性。该研究还旨在确定这些筛查测试之间的相关性。
进行了一项病例对照研究，涉及100名受试者，包括50名被诊断为DPN的患者和50名健康对照。参与者年龄在30至70岁之间，记录了空腹血糖、人体测量指标、DNE评分和VPT读数等各种参数。获得了伦理批准，并获得了所有参与者的知情同意。
研究结果表明，DNE评分的敏感性为80%，特异性为73.33%，而VPT的敏感性为70%，特异性为86.67%。当两种测试联合使用时，敏感性提高到90%，突出了通过多模式方法提高诊断准确性的潜力。
DNE评分与VPT一起使用时，为DPN的早期检测提供了一个强大的框架，特别是在资源可能有限的社区环境中。本研究强调了将简单有效的筛查技术纳入常规临床实践以降低糖尿病并发症相关风险的重要性。
