Friedlander Y, Kark J D, Stein Y
Clin Chem. 1985 Jul;31(7):1121-6.
We examined the variability of lipid and lipoprotein concentrations in plasma from a population sample from the Jerusalem Lipid Research Clinic study. Coefficients of variation of about 8% for plasma cholesterol, 11% to 15% for low- and high-density-lipoprotein cholesterol, and about 30% for triglyceride were reported, both for 17-year-olds and adults examined twice, with a median period of two months between measurements. Stability was similar in a subsample of adults who had an additional measurement a median of 28 months later. Within-assay analytical variation (CV) was 1.9-2.0% for cholesterol, 1.5-2.3% for triglyceride, and 4.5% for high-density-lipoprotein cholesterol. Between-assay variation was 3-5% for cholesterol and triglyceride and 10% for high-density-lipoprotein cholesterol. The lower stability of the lipoprotein fractions of cholesterol than of total cholesterol emphasizes the need for repeated measurements of these fractions for more accurate characterization of subjects, especially those with extreme values, both for clinical use and for predicting outcome in follow-up studies.
我们研究了耶路撒冷脂质研究诊所研究中人群样本血浆中脂质和脂蛋白浓度的变异性。报告显示，17岁青少年和成年人在两次检查中，血浆胆固醇变异系数约为8%，低密度和高密度脂蛋白胆固醇变异系数为11%至15%，甘油三酯变异系数约为30%，两次测量的中位间隔时间为两个月。在中位时间为28个月后进行了额外测量的成年亚组中，稳定性相似。胆固醇的批内分析变异（CV）为1.9 - 2.0%，甘油三酯为1.5 - 2.3%，高密度脂蛋白胆固醇为4.5%。胆固醇和甘油三酯的批间变异为3 - 5%，高密度脂蛋白胆固醇为10%。胆固醇脂蛋白部分的稳定性低于总胆固醇，这强调了对这些部分进行重复测量的必要性，以便更准确地表征受试者，特别是那些具有极端值的受试者，无论是用于临床还是在随访研究中预测结果。
