Jabarkhyl Dost, Perusseau-Lambert Aude, Fasuyi Joshua, Kostova Mariana, Anetekhai Christopher, Mistry Dillan, Harris Samuel, Yoshida Harue, Rahman Shafiq
General Internal Medicine, Luton and Dunstable University Hospital, Luton, GBR.
Plastic Surgery and Burns, St Andrew's Centre, Mid and South Essex National Health Service (NHS) Foundation Trust, Chelmsford, GBR.
Cureus. 2025 Feb 4;17(2):e78508. doi: 10.7759/cureus.78508. eCollection 2025 Feb.
Burn injuries in the paediatric population are common and account for a substantial proportion of hospital attendances, leading to a growing focus on optimising wound care to enhance healing, reduce discomfort and minimise the need for frequent dressing changes. Traditional dressings for superficial burns in children have inherent limitations that may hinder these goals. Biobrane (Dow Hickman/Bertek Pharmaceuticals, Sugar Land, TX), a semi-permeable silicone device embedded with a nylon mesh and a porcine-derived collagen matrix, offers a promising alternative with advantages such as improved wound healing, reduced pain and fewer dressing changes. This systematic review and meta-analysis, conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, assessed the efficacy of Biobrane by analysing data from MEDLINE, PubMed, EMCare, Cochrane Cochrane Central Register of Controlled Trials and additional clinical trial registries up to 8 June 2024. Primary outcomes included burn wound healing time, hospital length of stay and infection rate, while secondary outcomes assessed the need for split-thickness skin grafts (STSGs), pain and the number of dressing changes. Data synthesis using the OpenMetaAnalyst software (Brown University, Providence, RI) encompassed 781 burn wounds across 12 studies. The results showed that Biobrane significantly shortened wound healing time (mean difference, MD: 5.168 days, p = 0.001) and hospital length of stay (MD: 2.009 days, p < 0.001) compared to standard dressings. The infection rate was comparable (odds ratio, OR: 2.457, p = 0.132), and there was no difference in the requirement for STSGs (OR: 0.965, p = 0.956). This systematic review and meta-analysis demonstrate that Biobrane is an effective treatment for superficial paediatric burn injuries, offering faster wound healing, reduced pain and shorter hospital stays compared to traditional dressings.
小儿烧伤很常见，占医院就诊人数的很大比例，这使得人们越来越关注优化伤口护理，以促进愈合、减轻不适并尽量减少频繁换药的需求。儿童浅表烧伤的传统敷料存在固有局限性，可能会阻碍这些目标的实现。生物膜（Dow Hickman/Bertek Pharmaceuticals，得克萨斯州舒格兰）是一种半透性硅胶装置，内嵌尼龙网和猪源胶原蛋白基质，具有促进伤口愈合、减轻疼痛和减少换药次数等优势，提供了一种很有前景的替代方案。本系统评价和荟萃分析按照系统评价和荟萃分析的首选报告项目指南进行，通过分析截至2024年6月8日来自MEDLINE、PubMed、EMCare、Cochrane对照试验中央注册库及其他临床试验注册库的数据，评估了生物膜的疗效。主要结局包括烧伤创面愈合时间、住院时间和感染率，次要结局评估了对中厚皮片移植的需求、疼痛和换药次数。使用OpenMetaAnalyst软件（布朗大学，罗德岛州普罗维登斯）进行数据合成，涵盖了12项研究中的781个烧伤创面。结果显示，与标准敷料相比，生物膜显著缩短了伤口愈合时间（平均差，MD：5.168天，p = 0.001）和住院时间（MD：2.009天，p < 0.001）。感染率相当（比值比，OR：2.457，p = 0.132），中厚皮片移植需求无差异（OR：0.965，p = 0.956）。本系统评价和荟萃分析表明，生物膜是治疗小儿浅表烧伤的有效方法，与传统敷料相比，能加快伤口愈合、减轻疼痛并缩短住院时间。
