Zhou Haiying, Chen Yangwu, Yan Wu, Chen Xiao, Zi Yin
Department of Orthopedic Surgery of Sir Run Run Shaw Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China.
Department of Sports Medicine & Orthopedic Surgery, The Second Affiliated Hospital, and Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China.
Bioact Mater. 2025 Feb 20;47:531-545. doi: 10.1016/j.bioactmat.2025.01.001. eCollection 2025 May.
Tendon and enthesis injuries are a global health problem affecting millions of people, causing huge medical expenditure and labor loss every year. However, due to their intricate tissue architecture, unique mechanical properties, and especially their sluggish and limited innate regenerative capacity, repairing these injuries remains a formidable clinical challenge. Here, we present a comprehensive review of biomaterials advances in tendon and enthesis repair recently. These biomaterials are categorized into two primary groups based on their potential clinical application conditions: biomaterials for T/E repairing and biomaterials for T/E replacement. The T/E repairing biomaterials were further divided into two groups: mechanical-enhanced biomaterials and bioactive biomaterials, according to the approaches they used to improve sutured tendon healing. We delve into the characteristics and underlying mechanisms of these various biomaterials to gain a deeper understanding of the current landscape in tendon and enthesis repair biomaterials. This review aims to highlight the prominent advancements while identifying the remaining gaps, ultimately inspiring future biomaterial design strategies.
肌腱和附着点损伤是一个全球性的健康问题，影响着数百万人，每年造成巨额医疗费用和劳动力损失。然而，由于其复杂的组织结构、独特的力学性能，尤其是其缓慢且有限的固有再生能力，修复这些损伤仍然是一项艰巨的临床挑战。在此，我们对近期肌腱和附着点修复中生物材料的进展进行了全面综述。根据其潜在的临床应用条件，这些生物材料主要分为两类：用于肌腱/附着点修复的生物材料和用于肌腱/附着点替代的生物材料。根据改善缝合肌腱愈合的方法，用于肌腱/附着点修复的生物材料又进一步分为两组：机械增强型生物材料和生物活性生物材料。我们深入探讨了这些不同生物材料的特性和潜在机制，以更深入地了解肌腱和附着点修复生物材料的当前状况。本综述旨在突出显著进展，同时找出尚存差距，最终激发未来生物材料设计策略。
