性别对先天性无胸腺（裸）小鼠滴虫病发病机制的影响。
Influence of gender in pathogenesis of trichomoniasis in congenitally athymic (nude) mice.
作者信息
Martinotti M G, Musso T, Savoia D
机构信息
Institute of Microbiology, University of Turin, Italy.
出版信息
Genitourin Med. 1988 Feb;64(1):18-21. doi: 10.1136/sti.64.1.18.
Evaluation of abscesses appearing in male and female euthymic and athymic (nude) Balb/c mice after subcutaneous injection of Trichomonas vaginalis in the dorsal region showed that females were more susceptible than males. Female euthymic mice, however, were more susceptible than male athymic mice, and splenectomised athymic males were more susceptible than non-splenectomised athymic males. F1 female athymic mice were the most susceptible, as their abscesses reached a peak size five days earlier than those of athymic homozygous females. F1 male athymic mice, though slightly more susceptible than athymic homozygous males, did not develop abscesses that were similar in size. These results suggest that resistance or susceptibility to T vaginalis infection depends on the gender of the host and on thymus dependent cellular populations.
在雄性和雌性正常胸腺及无胸腺（裸）Balb/c小鼠的背部皮下注射阴道毛滴虫后，对出现的脓肿进行评估，结果显示雌性比雄性更易感染。然而，正常胸腺的雌性小鼠比无胸腺的雄性小鼠更易感染，并且脾切除的无胸腺雄性小鼠比未脾切除的无胸腺雄性小鼠更易感染。F1代无胸腺雌性小鼠最易感染，因为它们的脓肿在比无胸腺纯合雌性小鼠早五天达到最大尺寸。F1代无胸腺雄性小鼠虽然比无胸腺纯合雄性小鼠稍易感染，但未形成大小相似的脓肿。这些结果表明，对阴道毛滴虫感染的抵抗力或易感性取决于宿主的性别和胸腺依赖性细胞群体。
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