Chu P, Cadley M, Bellingham A J
Clin Lab Haematol. 1985;7(1):1-5. doi: 10.1111/j.1365-2257.1985.tb00001.x.
The mechanism of the increased haemoglobin (Hb) and erythrocyte survival in continuous ambulatory peritoneal dialysis (CAPD) compared to haemodialysis (HD) was investigated by measuring hexose monophosphate shunt (HMP) activity and reduced glutathione concentration (GSH) in 12 patients--six patients who were stable on CAPD, and six patients who were stable on HD, and also six normal controls. We confirmed the rise in haemoglobin in the CAPD group. The HMP activity, measured by the liberation of 14CO2 from radioactive glucose labelled at the C1 position shows that both HD and CAPD groups fall into the normal range (normal 3-11%) although the HMP activity is higher in the HD group. The reduced glutathione concentration in the three groups was: normal controls 2.41 +/- 0.19 mmol/l; HD 3.31 +/- 0.43 mmol/l; CAPD 2.68 +/- 0.24 mmol/l. The HD group is significantly higher (P less than 0.01) than both normal and CAPD. We conclude that the rise in haemoglobin in CAPD patients is not related to a more effective HMP. This suggests other mechanisms i.e. marrow function or red-cell loss in HD may be the reason for the lower haemoglobin in this group.
通过测量12名患者（6名持续性非卧床腹膜透析（CAPD）稳定患者、6名血液透析（HD）稳定患者以及6名正常对照者）的磷酸己糖旁路（HMP）活性和还原型谷胱甘肽浓度（GSH），研究了与血液透析（HD）相比，持续性非卧床腹膜透析（CAPD）中血红蛋白（Hb）增加和红细胞存活时间延长的机制。我们证实了CAPD组中血红蛋白的升高。通过测量标记于C1位置的放射性葡萄糖释放的14CO2来测定HMP活性，结果显示HD组和CAPD组的HMP活性均在正常范围内（正常范围为3%-11%），尽管HD组的HMP活性更高。三组中还原型谷胱甘肽浓度分别为：正常对照者2.41±0.19 mmol/l；HD组3.31±0.43 mmol/l；CAPD组2.68±0.24 mmol/l。HD组显著高于正常组和CAPD组（P<0.01）。我们得出结论，CAPD患者血红蛋白升高与更有效的HMP无关。这表明其他机制，即HD中骨髓功能或红细胞丢失可能是该组血红蛋白较低的原因。
