Gao Jie, Chen Fuqian, Wang Chen, Yang Jingbo, Zheng Ying, Liu Bin, Nie Gang, Zhu Linyu, Wu Shuo, Xie Xi, Jiang Lelun
Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Biomedical Engineering, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, 518107, PR China.
Department of Dermatovenereology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518107, PR China.
Microsyst Nanoeng. 2025 Mar 10;11(1):46. doi: 10.1038/s41378-024-00823-0.
Hypertrophic scar (HS) is a plaque fibrous and indurated dermal lesion that may cause physical, psychological, and cosmetic challenges for patients. Intralesional injection of triamcinolone acetonide (TA) is commonly used in clinical practice, which cause unbearable pain and uneven drug delivery within HS tissue. Herein, we developed a paper battery powered iontophoresis-driven microneedles patch (PBIMNP) for self-management of HS. The high integration of PBIMNP was achieved by incorporating a paper battery as the power source for iontophoresis. The transdermal drug delivery strategy of PBIMNP combined microneedles and iontophoresis techniques, involving "pressing and poking, phase transformation, and diffusion and iontophoresis", which can actively deliver 90.19% drug into the HS tissue with excellent in vitro drug permeation performance. PBIMNP administration effectively reduced the mRNA and protein levels, leading to a decrease in the expression of TGF-β1 and Col I associated with HS formation, demonstrating its efficacy in HS treatment. The microneedles and wearable design endow the PBIMNP as a highly promising platform for self-administration on HS treatment.
肥厚性瘢痕（HS）是一种斑块状纤维性硬结性皮肤病变，可能给患者带来身体、心理和美容方面的问题。曲安奈德（TA）皮损内注射是临床常用的治疗方法，但会在HS组织内引起难以忍受的疼痛且药物递送不均匀。在此，我们开发了一种由纸质电池供电的离子电渗驱动微针贴片（PBIMNP）用于HS的自我管理。通过将纸质电池作为离子电渗的电源，实现了PBIMNP的高度集成。PBIMNP的透皮给药策略结合了微针和离子电渗技术，包括“按压刺入、相变以及扩散和离子电渗”，其能够将90.19%的药物有效递送至HS组织，体外药物渗透性能优异。PBIMNP给药有效降低了mRNA和蛋白质水平，导致与HS形成相关的TGF-β1和I型胶原表达下降，证明了其在HS治疗中的疗效。微针和可穿戴设计使PBIMNP成为HS治疗自我给药的极具前景的平台。
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