College of Chemistry, Jilin University, Changchun, 130012, China.
State Key Laboratory of Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun, 130012, China.
Nat Commun. 2023 Jan 18;14(1):297. doi: 10.1038/s41467-023-35990-7.
Wearable transdermal iontophoresis eliminating the need for external power sources offers advantages for patient-comfort when deploying epidermal diseases treatments. However, current self-powered iontophoresis based on energy harvesters is limited to support efficient therapeutic administration over the long-term operation, owing to the low and inconsistent energy supply. Here we propose a simplified wearable iontophoresis patch with a built-in Mg battery for efficient and controllable transdermal delivery. This system decreases the system complexity and form factors by using viologen-based hydrogels as an integrated drug reservoir and cathode material, eliminating the conventional interface impedance between the electrode and drug reservoir. The redox-active polyelectrolyte hydrogel offers a high energy density of 3.57 mWh cm, and an optimal bioelectronic interface with ultra-soft nature and low tissue-interface impedance. The delivery dosage can be readily manipulated by tuning the viologen hydrogel and the iontophoresis stimulation mode. This iontophoresis patch demonstrates an effective treatment of an imiquimod-induced psoriasis mouse. Considering the advantages of being a reliable and efficient energy supply, simplified configuration, and optimal electrical skin-device interface, this battery-powered iontophoresis may provide a new non-invasive treatment for chronic epidermal diseases.
可穿戴经皮离子电渗疗法无需外部电源，为治疗表皮疾病提供了患者舒适性方面的优势。然而，目前基于能量收集器的自供电离子电渗疗法由于能量供应低且不一致，限制了其在长期运行中支持高效治疗的能力。在这里，我们提出了一种简化的可穿戴离子电渗疗法贴片，内置 Mg 电池，用于高效和可控的经皮给药。该系统通过使用基于紫精的水凝胶作为集成药物储存库和阴极材料，减少了系统复杂性和外形因素，消除了电极和药物储存库之间的传统界面阻抗。具有氧化还原活性的聚电解质水凝胶提供了 3.57 mWh cm 的高能量密度，以及具有超柔软特性和低组织界面阻抗的最佳生物电子界面。通过调节紫精水凝胶和离子电渗刺激模式，可以轻松控制输送剂量。该离子电渗疗法贴片有效治疗了咪喹莫特诱导的银屑病小鼠。考虑到作为可靠且高效的能源供应、简化的配置以及最佳电皮肤器件接口的优势，这种电池供电的离子电渗疗法可能为慢性表皮疾病提供一种新的非侵入性治疗方法。
