Venkataraman A, Jia T, Ruderman S A, Haas C B, Nance R M, Mixson L S, Mayer K H, Saag M S, Chander G, Moore R D, Jacobson J, Napravnik S, Christopolous K, Lee W J, Whitney B M, Peter I, Crane H M, Delaney J A C, Lindström S
University of Washington, Seattle, WA, USA.
Harvard University, Cambridge, MA, USA.
BMC Med Genomics. 2025 Mar 11;18(1):46. doi: 10.1186/s12920-025-02105-8.
Amphetamine-like stimulants are the most used psychostimulants in the world; methamphetamine use is the most prevalent in people with HIV. Prolonged methamphetamine use can cause lasting damage to the heart, gut, and brain, as well as auditory hallucinations and paranoid thinking. However, relatively little is known about methamphetamine use and its genetic contributors.
Using genetic information from the Centers for AIDS Research Network of Integrated Clinical Systems (CNICS) cohort, we conducted a multi-ancestry genome-wide association study (GWAS) of methamphetamine use among people with HIV (n = 1,196 reported ever use, n = 4,750 reported never use).
No single nucleotide polymorphism was statistically associated with methamphetamine use at the genome-wide level (p < 5 * 10) in our study. Further, we did not replicate previously suggested genetic variants from other studies (all p > 0.05 in our analysis).
Our study suggests that there is no single strong genetic contributor to lifetime use of methamphetamine in people with HIV enrolled in CNICS. Larger studies with more refined outcome assessment are warranted to further understand the contribution of genetics to methamphetamine use and use disorder. Investigation into social and environmental contributors to methamphetamine use are similarly necessary.
苯丙胺类兴奋剂是世界上使用最广泛的精神兴奋剂；甲基苯丙胺的使用在艾滋病毒感染者中最为普遍。长期使用甲基苯丙胺会对心脏、肠道和大脑造成永久性损伤，还会导致幻听和偏执思维。然而，关于甲基苯丙胺的使用及其遗传因素，人们了解得相对较少。
利用综合临床系统艾滋病研究网络（CNICS）队列的遗传信息，我们对艾滋病毒感染者中的甲基苯丙胺使用情况进行了多血统全基因组关联研究（GWAS）（n = 1196报告曾使用，n = 4750报告从未使用）。
在我们的研究中，没有单核苷酸多态性在全基因组水平上与甲基苯丙胺使用存在统计学关联（p < 5 * 10）。此外，我们没有重复其他研究中先前提出的遗传变异（我们的分析中所有p > 0.05）。
我们的研究表明，对于纳入CNICS的艾滋病毒感染者，没有单一强大的遗传因素导致其终生使用甲基苯丙胺。需要开展更大规模且结局评估更精细的研究，以进一步了解遗传学对甲基苯丙胺使用及使用障碍的影响。同样有必要调查甲基苯丙胺使用的社会和环境因素。
