TyG指数在中国中老年人群昼夜节律综合征与癌症关系中的中介作用

The mediating role of the TyG index in the relationship between circadian syndrome and cancer among middle-aged and elderly Chinese.

作者信息

Bai Zilong, Liang Jiale, Nie Yuanhua, Wang Shilong, Chang Dongmin

机构信息

Department of Surgical Oncology, The First Affiliated Hospital of Xi' an Jiaotong University, Xi'an, 710061, Shanxi, China.

出版信息

BMC Cancer. 2025 Mar 10;25(1):431. doi: 10.1186/s12885-025-13816-7.

DOI:10.1186/s12885-025-13816-7

PMID:40065285

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11895363/

Abstract

BACKGROUND

Circadian Syndrome (CircS) is a significant marker of metabolic imbalance and has been linked to various chronic diseases. However, its relationship with cancer risk remains underexplored. This research aims to explore the relationship between CircS and cancer, while also assessing the possible mediating role of the triglyceride glucose (TyG) index.

METHODS

Baseline data from the 2011 China Health and Retirement Longitudinal Study (CHARLS) and follow-up data from 2015 were analyzed, including participants' sociodemographic characteristics, health behaviors, and metabolic indicators. Linear regression, mediation analysis, and logistic regression were employed to explore relationships between CircS, cancer risk, and the TyG index, with a dose-response analysis conducted on TyG index and cancer risk.

RESULTS

Among 7,864 middle-aged and elderly participants, CircS was significantly and positively associated with cancer risk (r = 0.17, P < 0.001). The TyG index showed a significant correlation with both CircS (r = 0.52, P < 0.001) and cancer (r = 0.15, P < 0.001). Mediation modeling indicated that the TyG index partially mediated the association between CircS and cancer, accounting for 23% of this relationship. Additionally, a significant nonlinear dose-response relationship was observed between the TyG index and cancer risk (P = 0.0024).

CONCLUSION

Circadian syndrome is associated with increased cancer risk, with the TyG index partially mediating this relationship.

摘要

背景

昼夜节律综合征（CircS）是代谢失衡的一个重要标志物，并且与多种慢性疾病相关。然而，其与癌症风险之间的关系仍未得到充分研究。本研究旨在探讨CircS与癌症之间的关系，同时评估甘油三酯葡萄糖（TyG）指数可能的中介作用。

方法

分析了2011年中国健康与养老追踪调查（CHARLS）的基线数据以及2015年的随访数据，包括参与者的社会人口学特征、健康行为和代谢指标。采用线性回归、中介分析和逻辑回归来探讨CircS、癌症风险和TyG指数之间的关系，并对TyG指数和癌症风险进行剂量反应分析。

结果

在7864名中老年参与者中，CircS与癌症风险显著正相关（r = 0.17，P < 0.001）。TyG指数与CircS（r = 0.52，P < 0.001）和癌症（r = 0.15，P < 0.001）均显著相关。中介模型表明，TyG指数部分介导了CircS与癌症之间的关联，占这种关系的23%。此外，在TyG指数与癌症风险之间观察到显著的非线性剂量反应关系（P = 0.0024）。