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老年膀胱癌患者行根治性膀胱切除术后采用回肠原位新膀胱、输尿管皮肤造口术或回肠膀胱术的健康相关生活质量:使用经过验证的问卷进行的横断面研究。

Health-related quality of life after radical cystectomy for bladder cancer in elderly patients with ileal orthotopic neobladder, ureterocutaneostomy or ileal conduit: cross-sectional study using validated questionnaires.

作者信息

Altunkol Adem, Alma Ergün, Vuruşkan Ediz, Çetinkökü Gökay, Karkin Kadir, Aydamirov Mubariz, Aksay Buğra, Yelsel Kazım, Akgün Ömer Faruk

机构信息

Department of Urology, University of Health Sciences, Adana City Teaching and Research Hospital, Adana, Turkey.

Application and Research Center, Başkent University, Alanya, Turkey.

出版信息

BMC Urol. 2025 Mar 10;25(1):46. doi: 10.1186/s12894-025-01730-w.

DOI:10.1186/s12894-025-01730-w
PMID:40065307
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11892295/
Abstract

PURPOSE

The most appropriate form of urinary diversion (UD) after radical cystectomy remains controversial. In this study, we aimed to compare the health-related quality of life questionnaire results of patients who underwent orthotopic neobladder (ONB), ureterocutaneostomy (UC) and ileal conduit (IC) diversion.

MATERIALS

A total of 92 patients, including 42 out of 65 IC patients, 11 out of 15 ONB patients, and 39 out of 59 UC patients, completed the SF-36 and Barthel index quality of life questionnaires.

RESULTS

The mean follow-up periods were 11.7 ± 13.5 months for UC patients, 24.2 ± 20.8 months for IC patients, and 34.3 ± 25 months for ONB patients. The drain removal times were 5.7 ± 2.3 days in the UC group, 7 ± 2.8 days in the IC group, and 10.9 ± 9.2 days in the ONB group, with both the follow-up and drain removal periods being shorter in the UC group (P < 0.001; P = 0.002). Significant differences were noted in quality of life scores, particularly for emotional function (P = 0.016) and fatigue (P = 0.001), with the ONB group having higher emotional function scores and the UC group having higher fatigue scores than the other groups did.

CONCLUSION

Although there was no significant difference in terms of quality of life among the three methods, according to our results, we concluded that ONB should be performed in healthy, young, fit patients, especially those with body image expectations, and that UC should be performed in high-risk elderly patients. Although the selection of UD is based on individual considerations and the experience of the physician, quality of life questionnaires and patient counseling have critical importance.

摘要

目的

根治性膀胱切除术后最合适的尿流改道(UD)形式仍存在争议。在本研究中,我们旨在比较接受原位新膀胱(ONB)、输尿管皮肤造口术(UC)和回肠膀胱术(IC)改道的患者的健康相关生活质量问卷结果。

材料

共有92例患者完成了SF - 36和Barthel指数生活质量问卷,其中包括65例IC患者中的42例、15例ONB患者中的11例以及59例UC患者中的39例。

结果

UC患者的平均随访期为11.7±13.5个月,IC患者为24.2±20.8个月,ONB患者为34.3±25个月。UC组的引流管拔除时间为5.7±2.3天,IC组为7±2.8天,ONB组为10.9±9.2天,UC组的随访期和引流管拔除期均较短(P<0.001;P = 0.002)。生活质量评分存在显著差异,尤其是在情感功能(P = 0.016)和疲劳(P = 0.001)方面,ONB组的情感功能评分高于其他组,UC组的疲劳评分高于其他组。

结论

虽然三种方法在生活质量方面没有显著差异,但根据我们的结果,我们得出结论,ONB应在健康、年轻、身体状况良好的患者中进行,尤其是那些对身体形象有期望的患者,而UC应在高危老年患者中进行。虽然UD的选择基于个人考虑和医生的经验,但生活质量问卷和患者咨询至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa97/11892295/4b16664a7650/12894_2025_1730_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa97/11892295/4b16664a7650/12894_2025_1730_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa97/11892295/4b16664a7650/12894_2025_1730_Fig1_HTML.jpg

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本文引用的文献

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Urology. 2023 Nov;181:162-166. doi: 10.1016/j.urology.2023.08.018. Epub 2023 Sep 7.
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Impairment in Activities of Daily Living Assessed by the Barthel Index Predicts Adverse Oncological Outcomes After Radical Cystectomy for Bladder Cancer.通过巴氏指数评估的日常生活活动能力受损可预测膀胱癌根治性膀胱切除术后的不良肿瘤学结局。
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Impact of functional impairment and cognitive status on perioperative outcomes and costs after radical cystectomy: The role of Barthel Index.
功能障碍和认知状态对根治性膀胱切除术后围手术期结局及费用的影响:巴氏指数的作用
Int J Urol. 2023 Apr;30(4):366-373. doi: 10.1111/iju.15134. Epub 2022 Dec 28.
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World J Urol. 2022 Dec;40(12):3091-3097. doi: 10.1007/s00345-022-04211-z. Epub 2022 Nov 8.
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