ChEMBL的十五年及其在化学信息学和药物发现中的作用。

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, CB101SD, UK.

J Cheminform. 2025 Mar 10;17(1):32. doi: 10.1186/s13321-025-00963-z.

In October 2024 we celebrated the 15th anniversary of the first launch of ChEMBL, Europe's most impactful, open-access drug discovery database, hosted by EMBL's European Bioinformatics Institute (EMBL-EBI). This is a good moment to reflect on ChEMBL's history, the role that ChEMBL plays in Cheminformatics and Drug Discovery as well as innovations accelerated using data extracted from it. The review closes by discussing current challenges and possible directions that need to be taken to guarantee that ChEMBL continues to be the pioneering resource for highly curated, open bioactivity data on the European continent and beyond.

2024年10月，我们庆祝了ChEMBL首次发布15周年。ChEMBL是欧洲最具影响力的开放获取药物发现数据库，由欧洲分子生物学实验室的欧洲生物信息学研究所（EMBL-EBI）主办。这是一个回顾ChEMBL历史、ChEMBL在化学信息学和药物发现中所起作用以及利用从中提取的数据加速创新的好时机。本文最后讨论了当前面临的挑战以及为确保ChEMBL继续成为欧洲大陆及其他地区经过高度整理的开放生物活性数据的开创性资源而需要采取的可能方向。