Wanebo H J
Head Neck Surg. 1979 Sep-Oct;2(1):42-55. doi: 10.1002/hed.2890020107.
Patients with squamous cancer of the head and neck have unique perturbations of the immune system. These patients have marked depression of cellular immunity even in the early stages of disease. The known facts about the immunobiology and the immunodeficiencies that commonly occur are discussed. Also reviewed are the relationships of the immunologic deficits to stage of disease, to prognosis, and to the suspected etiologic factors of smoking, alcoholism, and malnutrition. Highlights are given of current immunotherapeutic trials. To date, most of the successful efforts in both immunologic research and immunotherapy of head and neck cancer have dealt with general, rather than specific, immune reactions. Further development in the area of specific immune responses may permit more meaningful measurements of tumor-specific reactions, thus yielding useful tools for immunodiagnosis as well as providing more effective and precise methods of immunotherapy.
头颈部鳞状癌患者存在免疫系统的独特紊乱。即使在疾病早期，这些患者的细胞免疫也会显著降低。文中讨论了关于免疫生物学和常见免疫缺陷的已知事实。还回顾了免疫缺陷与疾病分期、预后以及吸烟、酗酒和营养不良等疑似病因之间的关系。重点介绍了当前的免疫治疗试验。迄今为止，头颈部癌症免疫研究和免疫治疗方面的大多数成功努力都涉及一般免疫反应，而非特异性免疫反应。特异性免疫反应领域的进一步发展可能会使肿瘤特异性反应的测量更有意义，从而产生用于免疫诊断的有用工具，并提供更有效、精确的免疫治疗方法。
