Maryanchik S V, Borovikova S E, Ivanova A O, Trofimov V V, Bagrova O E, Frolova A S, Mityaeva O N, Volchkov P Yu, Deviatkin A A
Institute of Translational Medicine, Pirogov Russian National Research Medical University, Moscow, Russia.
Institute of Gene Biology Russian Academy of Sciences (RAS), Moscow, Russia.
Front Cell Infect Microbiol. 2025 Feb 24;15:1436026. doi: 10.3389/fcimb.2025.1436026. eCollection 2025.
Viruses are obligate parasites, that use the host's internal metabolic systems for their own reproduction. This complicates the search for molecular targets to prevent the spread of viral infection without disrupting the vital functions of human cells. Defective interfering particles (DIPs) are natural competitors of viruses for important resources of viral reproduction. DIPs emerge during infection, originate from the normal viral replication process and inhibit its progression, making them an interesting candidate for antiviral therapy. Here we describe the biology of DIPs, advances in DIP-based antiviral technology, analyze their therapeutic potential and provide a systemic overview of existing preventive and therapeutic antiviral strategies.
病毒是专性寄生虫，它们利用宿主的内部代谢系统进行自身繁殖。这使得在不干扰人体细胞重要功能的情况下寻找防止病毒感染传播的分子靶点变得复杂。缺陷干扰颗粒（DIPs）是病毒在病毒繁殖重要资源方面的天然竞争者。DIPs在感染过程中出现，源自正常的病毒复制过程并抑制其进展，这使它们成为抗病毒治疗的一个有吸引力的候选者。在这里，我们描述了DIPs的生物学特性、基于DIP的抗病毒技术的进展，分析了它们的治疗潜力，并对现有的预防性和治疗性抗病毒策略进行了系统概述。
