Chen Rong, Zhang Wan, Zhang Meizhi, Liu Weidong, Feng Weike, Zhang Yanan
College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Graduate School of Dalian Medical University, Dalian, Liaoning, China.
Front Pharmacol. 2025 Feb 24;16:1545654. doi: 10.3389/fphar.2025.1545654. eCollection 2025.
Medicinal plants are crucial in the comprehensive treatment of anti-tumor with the advantages of high efficacy, low toxicity, multiple pathways and multi-targets synergy, leading to be a focal point of study for many oncologists. Identifying effective monomer components with anti-tumor properties from medicinal plants has long been a crucial focus in the study and development of traditional Chinese medicine. This endeavor has significant research value and promising possibilities for further advancement. Asiatic Acid (AA), a pentacyclic triterpenoid derived from (L.) Urb, is used in traditional Chinese medicine and has been shown to have anti-tumor properties on a range of tumor types. The present study assessed the anti-tumor properties of AA from five different perspectives: inhibiting proliferation, inducing apoptosis, inhibiting invasion and metastasis, regulating cell autophagy, enhancing the resistance of tumor cells to drugs, and minimizing adverse side effects.
药用植物在抗肿瘤综合治疗中至关重要，具有高效、低毒、多途径和多靶点协同等优势，成为众多肿瘤学家的研究重点。从药用植物中鉴定出具有抗肿瘤特性的有效单体成分一直是中药研究与开发的关键焦点。这一努力具有重要的研究价值和进一步推进的广阔前景。积雪草苷（AA）是一种从积雪草中提取的五环三萜类化合物，在传统中药中应用，已显示出对多种肿瘤类型具有抗肿瘤特性。本研究从抑制增殖、诱导凋亡、抑制侵袭和转移、调节细胞自噬、增强肿瘤细胞对药物的抗性以及最小化不良反应等五个不同角度评估了积雪草苷的抗肿瘤特性。
