Nelson R L, Samelson S L
Dis Colon Rectum. 1985 Jun;28(6):460-2. doi: 10.1007/BF02560238.
There is an epidemiologic association between beer consumption and rectal cancer. Beer and ethanol were tested in the rat-dimethylhydrazine (DMH) experimental carcinogenesis model in order to verify this observation. Ethanol was found not to affect the number of colonic tumors induced by DMH (86 vs. 77 controls, P = 0.764). In rats fed beer and treated with DMH, there was a decrease in gastrointestinal tumor induction (P = 0.043). This instance then becomes one of many in which conclusions drawn from epidemiologic studies have been contradicted when subjected to analysis in an experimental colon carcinogenesis model.
啤酒消费与直肠癌之间存在流行病学关联。为了验证这一观察结果，在大鼠二甲基肼（DMH）实验性致癌模型中对啤酒和乙醇进行了测试。结果发现，乙醇不影响由DMH诱导的结肠肿瘤数量（86个肿瘤vs.77个对照，P = 0.764）。在喂食啤酒并接受DMH处理的大鼠中，胃肠道肿瘤诱导有所减少（P = 0.043）。因此，这一情况成为了众多案例之一，即在实验性结肠癌发生模型中进行分析时，流行病学研究得出的结论被推翻。
