Cope G F, Wyatt J I, Pinder I F, Lee P N, Heatley R V, Kelleher J
Department of Medicine, St James's University Hospital, Leeds.
Gut. 1991 Jan;32(1):70-2. doi: 10.1136/gut.32.1.70.
The risk of developing colorectal adenomatous polyps is probably increased by a variety of dietary and environmental factors. We found an association with current alcohol and cigarette consumption. The risk of polyps was increased three times in drinkers who did not smoke and two times in smokers who did not drink, with those who both drank and smoked having 12 times the risk of total abstainers. Since colonic adenomatous polyps are generally regarded as premalignant lesions, these results lend support to the view that alcohol consumption may be an important factor in the pathogenesis of colorectal neoplasia, thus reinforcing the proposed polyp/carcinoma sequence in colorectal carcinogenesis. The role of smoking, however, is less clear particularly since the lack of association of colorectal carcinoma and smoking has been reported in many other studies.
多种饮食和环境因素可能会增加患大肠腺瘤性息肉的风险。我们发现这与当前饮酒和吸烟有关。不吸烟的饮酒者患息肉的风险增加了三倍，不饮酒的吸烟者患息肉的风险增加了两倍，而既饮酒又吸烟的人患息肉的风险是完全戒酒者的12倍。由于结肠腺瘤性息肉通常被视为癌前病变，这些结果支持了这样一种观点，即饮酒可能是大肠肿瘤发生机制中的一个重要因素，从而强化了在结直肠癌发生过程中提出的息肉/癌序列。然而，吸烟的作用尚不清楚，特别是因为许多其他研究报告结直肠癌与吸烟之间缺乏关联。
