Li Chunlei, Chen Yajun, Wu Hongmei, Zeng Yaqi, Li Yueying, Dong Jie, Wang Yujie, Song Tianqiang
Tianjin Medical University Cancer Institute & Hospital. National Clinical Research Center for Cancer. Tianjin's Clinical Research Center for Cancer.
Tianjin Medical University.
Nutr Hosp. 2025 Apr 21;42(2):302-310. doi: 10.20960/nh.05564.
Objectives: the impact of handgrip strength (HGS) on postoperative complications and long-term survival following hepatectomy in patients with primary liver cancer (PLC) remains unclear. This study aimed to evaluate the influence of HGS on postoperative complications and overall survival in patients with PLC. Methods: in total, 298 patients with PLC who underwent liver resection were included in the prospective cohort study. Baseline, surgical, and histopathological factors were analyzed using univariate and multivariate analyses to identify risk factors for postoperative complications and mortality. Results: the incidence of major postoperative complications was 40.3 % and 24.6 % in the low and high HGS groups, respectively. During the median follow-up period of 28.8 months, 57 patients (19.1 %) died. patients with low HGS demonstrated a significantly shorter median overall survival compared to those with high HGS (p < 0.001). Short-term analysis revealed that low HGS (p = 0.022) and intraoperative blood loss (≥ 200 ml) (p < 0.001) were independently associated with postoperative complications. Furthermore, low HGS was identified as an independent predictor of poor overall survival in long-term survival analysis (p = 0.005). Conclusions: preoperative HGS emerged as an independent factor for postoperative complications and a prognostic indicator of poor long-term outcomes in patients with PLC.
原发性肝癌（PLC）患者肝切除术后握力（HGS）对术后并发症及长期生存的影响尚不清楚。本研究旨在评估HGS对PLC患者术后并发症及总生存的影响。方法：前瞻性队列研究共纳入298例行肝切除的PLC患者。采用单因素和多因素分析对基线、手术及组织病理学因素进行分析，以确定术后并发症和死亡的危险因素。结果：低HGS组和高HGS组术后主要并发症发生率分别为40.3%和24.6%。在中位随访期28.8个月内，57例患者（19.1%）死亡。低HGS患者的中位总生存期明显短于高HGS患者（p<0.001）。短期分析显示，低HGS（p=0.022）和术中失血（≥200 ml）（p<0.001）与术后并发症独立相关。此外，在长期生存分析中，低HGS被确定为总生存不良的独立预测因素（p=0.005）。结论：术前HGS是PLC患者术后并发症的独立因素及长期预后不良的预后指标。
