Bu Fan, Yu Kai, Wang Jinnan, Rong Li, Li Qiaoyu
Department of Otolaryngology, Head, Neck and Plastic Surgery, Honghui Hospital, Xi'an Jiaotong University, Xian, China.
Department of Plastic and Aesthetic Surgery, Honghui Hospital, Xi'an Jiaotong University, Xian, China.
Medicine (Baltimore). 2025 Mar 7;104(10):e39970. doi: 10.1097/MD.0000000000039970.
The skin's integrity is vulnerable to external elements that can induce injuries, leading to wound formation. It's crucial to comprehend wound healing processes to protect the body when this protective barrier is compromised. Over the last 2 decades, there has been considerable progress in understanding delayed wound healing, with a focus on the mechanisms and microenvironmental factors involved. The connection between oxidative stress and wound healing has recently gained attention, emphasizing the need for in-depth analysis to propel further advancements and interventions in this area. Despite these advancements, there remains a noticeable void in the literature concerning the application of scientometric methods to systematically examine the progression of wound healing research. Additionally, a comprehensive assessment of the research output and effectiveness of various researchers and institutions in this field is lacking. To address these gaps, we analyzed data from the Web of Science Core Collection from January 1, 2000, to December 31, 2023, utilizing relevant keywords. Using CiteSpace, we created visual maps that depict the evolution and structure of keyword clusters, and both CiteSpace and VOSviewer were used to evaluate the performance of research networks across different countries, institutions, and authors. This data was methodically analyzed. The leading institution in this field is the Chinese Academy of Medical Sciences. The key researchers are Bekeschus, Sander; Li, Yang; Bi, Yang; Fan, Daidi; and Zhang, Yu. Our software analysis reviewed 3025 studies, revealing 19 co-citation clusters that highlight current trends in research on oxidative stress and wound healing. Prominent journals, leading institutions, and key researchers were identified. Key emerging research directions include studying the mechanisms linking oxidative stress to wound healing, exploring the use of antioxidant substances in wound dressings, and investigating how nanomaterials in dressings can influence oxidative stress. These focal points emphasize the significance of understanding oxidative stress's impact on wound healing and investigating new methods to enhance therapeutic efficacy. This comprehensive approach not only fills a gap in the current literature but also sets the stage for future research endeavors in this crucial area of health science.
皮肤的完整性易受可导致损伤的外部因素影响，从而形成伤口。当这一保护屏障受损时，了解伤口愈合过程对于保护身体至关重要。在过去20年里，在理解延迟伤口愈合方面取得了相当大的进展，重点是相关机制和微环境因素。氧化应激与伤口愈合之间的联系最近受到关注，强调需要进行深入分析以推动该领域的进一步进展和干预措施。尽管有这些进展，但文献中在应用科学计量方法系统检查伤口愈合研究进展方面仍存在明显空白。此外，缺乏对该领域不同研究人员和机构的研究产出及有效性的全面评估。为填补这些空白，我们利用相关关键词分析了2000年1月1日至2023年12月31日期间来自科学引文索引核心合集的数据。使用CiteSpace，我们创建了描绘关键词聚类演变和结构的可视化地图，并使用CiteSpace和VOSviewer评估不同国家、机构和作者的研究网络表现。对这些数据进行了系统分析。该领域的领先机构是中国医学科学院。关键研究人员有贝凯舒斯、桑德；李阳；毕阳；范代娣；以及张玉。我们的软件分析审查了3025项研究，揭示了19个共被引聚类，突出了氧化应激与伤口愈合研究的当前趋势。确定了著名期刊、领先机构和关键研究人员。关键的新兴研究方向包括研究氧化应激与伤口愈合之间的联系机制、探索抗氧化物质在伤口敷料中的应用，以及研究敷料中的纳米材料如何影响氧化应激。这些重点强调了理解氧化应激对伤口愈合的影响以及研究提高治疗效果新方法的重要性。这种全面方法不仅填补了当前文献中的空白，也为健康科学这一关键领域的未来研究努力奠定了基础。
