Xu Shangyi, Yang Kaiwen, Qiu Jin, Zhong Jianqiao, Xian Dehai
Emergency Medicine Department, Luzhou People's Hospital, Luzhou, China.
Anatomy Laboratory, Southwest Medical University, School of Basic Medicine, Luzhou, Cichuan, China.
Medicine (Baltimore). 2025 Mar 7;104(10):e41736. doi: 10.1097/MD.0000000000041736.
Psoriasis is a chronic inflammatory skin disease affecting 2% of the global population. Recent research suggests the skin microbiome plays a critical role in psoriasis. Skin microbiome data were obtained from the KORA FF4 study in Germany, and psoriasis data from FinnGen genome-wide association study summary statistics. Forward and reverse 2-sample Mendelian randomization (MR) analyses were conducted to assess causal relationships. Forward MR analysis identified several microbial features as risk factors for psoriasis, including the family Neisseriaceae in sebaceous skin (OR = 1.036, 95% CI: 1.010-1.062, P = .0054), ASV011 in dry skin (OR = 1.024, 95% CI: 1.000-1.048, P = .0490), and the order Clostridiales in moist skin (OR = 1.016, 95% CI: 1.000-1.032, P = .0449). Protective features included ASV016 (OR = 0.972, 95% CI: 0.949-0.994, P = .0136) and ASV053 (OR = 0.973, 95% CI: 0.954-0.992, P = .0054) in dry skin. Reverse MR analysis confirmed psoriasis as a significant risk factor for changes in the skin microbiome, with notable associations in the dry skin region for asv002 (OR = 1.266, 95% CI: 1.061-1.510, P = .027) and genus: Haemophilus (OR = 1.364, 95% CI: 1.065-1.746, P = .013). This study reveals bidirectional causal relationships between the skin microbiome and psoriasis, highlighting specific microbial features such as Neisseriaceae and Clostridiales as potential risk factors. Further research is needed to develop treatments that modulate the skin microbiome to improve psoriasis outcomes.
银屑病是一种慢性炎症性皮肤病，影响着全球2%的人口。最近的研究表明，皮肤微生物群在银屑病中起着关键作用。皮肤微生物群数据来自德国的KORA FF4研究，银屑病数据来自芬兰基因全基因组关联研究汇总统计。进行了正向和反向双样本孟德尔随机化（MR）分析以评估因果关系。正向MR分析确定了几种微生物特征为银屑病的风险因素，包括皮脂腺皮肤中的奈瑟菌科（比值比[OR]=1.036，95%置信区间[CI]：1.010-1.062，P=0.0054）、干性皮肤中的ASV011（OR=1.024，95%CI：1.000-1.048，P=0.0490）以及湿性皮肤中的梭菌目（OR=1.016，95%CI：1.000-1.032，P=0.0449）。保护特征包括干性皮肤中的ASV016（OR=0.972，95%CI：0.949-0.994，P=0.0136）和ASV053（OR=0.973，95%CI：0.954-0.992，P=0.0054）。反向MR分析证实银屑病是皮肤微生物群变化的一个重要风险因素，在干性皮肤区域，asv002（OR=1.266，95%CI：1.061-1.510，P=0.027）和嗜血杆菌属（OR=1.364，95%CI：1.065-1.746，P=0.013）有显著关联。这项研究揭示了皮肤微生物群与银屑病之间的双向因果关系，突出了奈瑟菌科和梭菌目等特定微生物特征作为潜在风险因素。需要进一步研究来开发调节皮肤微生物群以改善银屑病治疗效果的疗法。
