CRISPR-Cas: a game-changer in vaccine development and the fight against viral infections.
作者信息
Yang Fayu, Aliyari Saba, Zhu Zixiang, Zheng Haixue, Cheng Genhong, Zhang Shilei
机构信息
State Key Laboratory of Veterinary Etiological Biology, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China; Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou 730046, China.
Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA, USA.
出版信息
Trends Microbiol. 2025 Jun;33(6):650-664. doi: 10.1016/j.tim.2025.02.006. Epub 2025 Mar 10.
Understanding the mechanisms of virus-host interactions is crucial for advancing our knowledge of viral pathogenesis and developing effective antiviral strategies. As novel, highly virulent pathogens continue to emerge, overcoming the challenges in virus-host biology and infection control is more important than ever. The CRISPR-Cas system has revolutionized genetic engineering, offering a precise and efficient application in synthetic biology. It is also invaluable in virology research, diagnostics, and antiviral therapeutics. In this review, we explore the latest advances in CRISPR-Cas-based approaches to elucidate virus-host interactions, focusing on the identification of key receptors and host factors essential for virus infection. Furthermore, we discuss the potential of the CRISPR-Cas system as an antiviral strategy for tackling newly emerging and re-emerging viruses. Finally, we discuss the potential of CRISPR-Cas-based gene editing for the development of innovative viral vaccines.
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