Slany J, Ziegler B, Zajicek P, Karnik R
Eur Heart J. 1985 Feb;6(2):105-8. doi: 10.1093/oxfordjournals.eurheartj.a061822.
Selective coronary artery visualization was performed in the CCU by means of a movable fluoroscopy device in 96 patients with suspected myocardial infarction within 6 hours after onset of symptoms. Intracoronary streptokinase (SK) was administered in a total dosage of 200 000 to 400 000 U within 30-60 min to 69 patients with complete (N = 57) or subtotal obstruction (N = 12) of the infarct-related vessel. Recanalization was achieved in 39 of the 57 patients (68%) with initially complete occlusion. Three of the 39 successfully treated patients died (7.7%) versus 8 of 33 subjects (24%) with persistent complete obstruction (chi-square 3.21, not significant). Selective cineangiography subsequently performed in 8 patients and postmortem examination of 12 subjects who had died, showed that all haemodynamically significant lesions had been recognized by the examination in the CCU with one exception. It is concluded that intracoronary thrombolysis performed in the CCU, by means of a standard mobile fluoroscopy equipment is effective, safe, inexpensive and may be started virtually without delay after admission.
在冠心病监护病房（CCU），使用可移动荧光透视设备对96例症状发作后6小时内疑似心肌梗死的患者进行了选择性冠状动脉造影。在30 - 60分钟内，对69例梗死相关血管完全阻塞（N = 57）或次全阻塞（N = 12）的患者给予冠状动脉内链激酶（SK），总剂量为200000 - 400000单位。最初完全闭塞的57例患者中有39例（68%）实现了再通。39例成功治疗的患者中有3例死亡（7.7%），而33例持续完全阻塞的患者中有8例死亡（24%）（卡方检验值3.21，无显著性差异）。随后对8例患者进行了选择性电影血管造影，并对12例死亡患者进行了尸检，结果显示除1例例外，CCU的检查识别出了所有具有血流动力学意义的病变。得出的结论是，在CCU使用标准移动荧光透视设备进行冠状动脉内溶栓是有效、安全、廉价的，并且在入院后几乎可以立即开始。
