Raoufian Termeh, Pakbin Babak, Tabatabaee Bafroee Akram Sadat
Department of Biology, East Tehran Branch, Islamic Azad University, Tehran, Iran.
Werner Siemens Chair of Synthetic Biotechnology, Dept. of Chemistry, Technical University of Munich, 85748, Munich, Bavaria, Germany.
BMC Res Notes. 2025 Mar 11;18(1):110. doi: 10.1186/s13104-025-07113-6.
This research aims to investigate the epidemiology and genetic changes of Shigella species in the cities of Qazvin and Tehran from 2003 to 2023, with a focus on assessing antibiotic resistance among the isolates. This study is based on the analysis of 80 Shigella isolates, which were obtained from patients' feces.
Using pulsed-field gel electrophoresis (PFGE) as the primary typing method, the isolates were classified into 13 distinct clusters, revealing a dominant pattern that has persisted for over twenty years. This persistence may be attributed to factors such as poor hygiene, personal contact, immigration, and antibiotic resistance. Genetic analysis indicated clonal expansion among the isolates over the two-decade period. Notably, the highest resistance was observed against amoxicillin, with several isolates exhibiting multidrug resistance.
本研究旨在调查2003年至2023年加兹温市和德黑兰市志贺氏菌属的流行病学和基因变化，重点评估分离株中的抗生素耐药性。本研究基于对80株从患者粪便中获得的志贺氏菌分离株的分析。
以脉冲场凝胶电泳（PFGE）作为主要分型方法，分离株被分为13个不同的簇，揭示了一种持续了二十多年的主导模式。这种持续性可能归因于卫生条件差、人际接触、移民和抗生素耐药性等因素。基因分析表明，在二十年期间分离株中存在克隆扩增。值得注意的是，观察到对阿莫西林的耐药性最高，有几株分离株表现出多重耐药性。
