de Faria Valéria Cristina, Fernandes Juliana Simões de Alencar, Cunha Tulio Ericles de Oliveira, Pussieldi Guilherme de Azambuja, Pereira Danielle Aparecida Gomes
Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
Universidade do Norte do Paraná, Betim, MG, Brasil.
J Vasc Bras. 2025 Feb 24;24:e20230106. doi: 10.1590/1677-5449.202301062. eCollection 2025.
Early recognition of peripheral tissue perfusion deficits can minimize secondary complications of peripheral arterial disease in individuals with diabetes.
To compare parameters of peripheral tissue perfusion in the leg at rest and during and after progressive effort between non-diabetics and individuals with type 2 diabetes and normal ankle brachial index values, as well as to evaluate the factors associated with peripheral tissue perfusion in the leg in individuals with type 2 diabetes during progressive effort.
This cross-sectional study included 31 individuals with type 2 diabetes and 31 non-diabetics. Anthropometric measurements and physical activity levels were assessed in all individuals. Peripheral tissue perfusion was analyzed using near-infrared spectroscopy during an arterial occlusion maneuver and the Incremental Shuttle Walking Test.
During progressive effort, the tissue oxygen saturation level was lower in the type 2 diabetes group (type 2 diabetes, 58.74 [56.27-61.74] than the non-diabetic group, 62.15 [59.09-66.49]; p = 0.005). There were significant correlations between tissue oxygen saturation during progressive effort and physical activity level (p < 0.0001; r = -0.681), total body fat percentage (p = 0.001; r = 0.590), segmental body fat percentage (p < 0.0001; r = 0.616), total skeletal muscle mass (p < 0.0001; r = -0.628), and segmental skeletal muscle mass (p = 0.001; r = -0.592).
Individuals with type 2 diabetes and normal ankle-brachial index values had worse tissue perfusion during progressive effort than non-diabetics, and there was an association between perfusion, physical activity level, and body composition in the type 2 diabetes group.
早期识别外周组织灌注不足可将糖尿病患者外周动脉疾病的继发性并发症降至最低。
比较非糖尿病患者与2型糖尿病且踝肱指数正常的患者在静息状态下、进行性运动期间及运动后腿部外周组织灌注的参数，并评估2型糖尿病患者在进行性运动期间与腿部外周组织灌注相关的因素。
这项横断面研究纳入了31名2型糖尿病患者和31名非糖尿病患者。对所有个体进行人体测量和身体活动水平评估。在动脉闭塞操作和递增往返步行试验期间，使用近红外光谱分析外周组织灌注。
在进行性运动期间，2型糖尿病组的组织氧饱和度水平（2型糖尿病组为58.74[56.27 - 61.74]）低于非糖尿病组（62.15[59.09 - 66.49]）；p = 0.005。进行性运动期间的组织氧饱和度与身体活动水平（p < 0.0001；r = -0.681）、全身脂肪百分比（p = 0.001；r = 0.590）、节段性身体脂肪百分比（p < 0.0001；r = 0.616）、总骨骼肌质量（p < 0.0001；r = -0.628）和节段性骨骼肌质量（p = 0.001；r = -0.592）之间存在显著相关性。
2型糖尿病且踝肱指数正常的患者在进行性运动期间的组织灌注比非糖尿病患者差，并且在2型糖尿病组中，灌注、身体活动水平和身体成分之间存在关联。
